Advances in Pharmacokinetics and Pharmacodynamics

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.

Table of contents

Front Matter
Pages i-xi
Pharmacokinetics
Front Matter
Pages 1-1
Current Status in PBPK Modeling
Ryuta Asaumi, Kiyohiko Sugano
Pages 3-27
Physiologically Based Pharmacokinetic (PBPK) Modeling Application on Food Effect Assessment
Di Wu, John P. Gleeson, Filippos Kesisoglou
Pages 29-56
Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models: Inception and Development
Athanasios A. Tsekouras, Panos Macheras
Pages 57-81
Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models: Applications
Athanasios A. Tsekouras, Nikolaos Alimpertis, Panos Macheras
Pages 83-105
Pharmacodynamics
Front Matter
Pages 107-107
Pharmacokinetic–Pharmacodynamic Modeling and Simulation in Clinical Practice and Studies
Thomas P. C. Dorlo, Elin M. Svensson
Pages 109-135
On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body
Amin Rostami-Hodjegan, Brahim Achour
Pages 137-163
Impact of Clinical Pharmacology on the Modernization of Drug Development and Regulation
Liang Zhao, Carl C. Peck
Pages 165-202
Back Matter
Pages 203-204