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Alternative Splicing and Cancer

Alternative Splicing and Cancer
Alternative Splicing and Cancer
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This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.

TABLE OF CONTENTS

Preface

1. Alternative Splicing and Human Diseases

Mukesh Tanwar

2. Mechanism of RNA Splicing

Tabasum Ashraf, Humaira Shah, Rouf Maqbool, Auqib Manzoor and Ashraf Dar

3. Alternative Splicing: A New Cancer Hallmark

Mohd Younis Rather, Ajaz Ahmad Waza, Yasmeena Hassan and Sabhiya Majid

4. Deregulated Spliceosome and Splice Variants in Cancers

Farheen Naz

5. Deregulated Oncogenic Signaling Pathway(s) and Alternative Splicing

Bhawana and Pratyusha Vavilala

6. Alternative Splicing and Metastasis

Bilal A. Naikoo and Muzafar A. Macha

7. Role of Splice Variant of Pyruvate Kinase M2 (PKM2) in Cancer Metabolism

Mohd Amir, Ata Abbas, Saleem Javed, Saleh Alfuraih and Rais Ansari

8. Alternative Splicing and Immune Surveillance

Moumita Roy

9. Therapeutic Targeting of Alternative Splicing in Cancers

Sabra Parveen, Bilal Rah, Waseem Akram, Shahid Ali, Abdul Basit Baba, Shahnawaz A. Wani, Amrita Bhat, Itty Sethi and Gh. Rasool Bhat

10. Alternative Splicing in Cancer Drug Resistance

Ashna Gupta, Ravi Chauhan, Tarang Sharma, Muzafar A. Macha, Tariq Masoodi, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat and Mayank Singh

11. A Systematic Evaluation of Alternative Splicing and Cancer: A Review

Amrita Bhat, Ruchi Shah and Rakesh Kumar

Index

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