Brucella Melitensis, Identification and Characterization of Potential Drug Targets

• Covers the identification and characterization of vaccine targets for Brucella melitensis
• Presents in silico screening and the identification of novel drug targets
• Gives computational modeling and evaluations for potential drug targets
• Offers molecular docking and dynamics simulations for novel drug targets
• Details in silico validation and ADMET analysis for best lead molecules

Chapter 1: Introduction to Brucellosis
1.1. Brucellosis
1.2. Bioterrorism
1.3. Microbiology of Brucella
1.4. Summary
References

Chapter 2: Identification and characterization of vaccine targets for Brucella melitensis through in silico approaches
2.1. Introduction to subtractive genomics
2.2. Methodology to identify vaccine targets
2.3. Identification and characterization of drug targets
2.4. Summary
References

Chapter 3: Computational modeling and evaluation of best potential drug targets through comparative modeling
3.1. Introduction to protein modelling
3.2. Methodology for protein modelling
3.3. Identification of proteins as drug targets in B. melitensis and their modelling approaches
3.4. Summary
References

Chapter 4: Molecular docking and dynamics simulations of novel drug targets
4.1. Introduction to molecular docking
4.2. Methodology for molecular docking and dynamic simulations
4.3. Molecular docking and simulation studies of identified drug targets against selected ligands
4.4. Summary
References

Chapter 5: In silico validation and ADMET analysis for best lead molecules
5.1. Introduction to ADMET analysis
5.2. Methodology for ADMET analysis
5.3. ADMET analysis of best lead molecules against identified drug targets in B. melitensis 16M
5.4. Summary
References

Chapter 6: Summary and Conclusions