Lipid-Based Drug Delivery Systems: Principles and Applications, 1st Edition

This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. It covers the latest developments and advancements in the field of drug delivery, and explores and compiles information on the current situation of lipid-based formulations used as versatile excipients and all their possible routes to improve therapeutic benefits. The book discusses novel formulations such as depot formulations, micro- and nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, nanoliposomes, micelles, nanosuspensions, lipid implants and inserts, and lipid nanotubes. It presents preparation methods of LBDDSs and their physicochemical properties, and portrays their various application angles and their impacts on drug-conveyance frameworks when employed in vitro and in vivo. The book is beneficial for researchers working on lipid-based drug formulations as well as biological and translational drug delivery. It is also a useful resource for course work of students of various academic degree programs such as pharmacy, health sciences, biotechnology, and microbiology; postgraduate and PhD students; and postdoctoral fellows researching on nanomedicine-based drug delivery systems.

Contents

1. Lipid-Based Excipients: The Holy Grail in Pharmaceutical Product Development

2. Solid Lipid Nanoparticles

3. Liposomal Drug Delivery Systems: Concept and Recent Advances in Clinical Applications

4. Lipid-Based Drug Delivery System: Spotlight on Nanoemulsion as Versatile Nanocarrier

5. Lipid Nanocrystals: An Overview on Formulation to Clinical Translation

6. Cubosomes

7. Transfersomes as Transporters via Lipid-Based Drug Delivery System

8. Ethosomes: A Lipid-Based Drug Delivery System

9. Dendrimers: A Lipid-Based Drug Delivery System

10. Microbubbles

11. Phytosome and Herbosome: A Vesicular Drug Delivery System for Improving the Bioavailability of Natural Products

12. Role of Lipids in Depot Injectables

13. Role of Lipids in Vaccine Drug Delivery

14. Lipid-Based Drug Delivery in Cancer

15. Targeting Brain Using Lipid-Based Formulations

16. Role of Lipids in Ocular Drug Delivery Systems

17. Role of Lipids in Pulmonary Drug Delivery Systems

18. Food and Nutraceuticals

19. Role of Lipids in Cosmeceuticals

20. Regulatory Status of Lipids for Pharmaceuticals and Cosmeceuticals