Nano - and Microfabrication Techniques in Drug Delivery Recent Developments and Future Prospects

New materials and manufacturing techniques are evolving with the potential to address the challenges associated with the manufacture of medicinal products that will teach new tricks to old drugs. Nano- and microfabrication techniques include manufacturing methods such as additive manufacturing, lithography, micro-moulding, spray drying, and supercritical fluids among many others. The increasing resolution of new techniques allow researchers to produce objects with micrometric resolutions. This book follows a consecutive order, beginning with a background in the current field and limitations in the manufacturing of different pharmaceutical products, moving on the classification of each method by providing recent examples, and future prospective on a variety of traditional and new Nano and microfabrication techniques. A focus on the materials used to prepare these systems and their biocompatibility, including applied topics such as clinical applications and regulatory aspects also covered, offering the reader a holistic view of this rapidly growing field.

Table of contents

Front Matter
Pages i-xiiiConducting Polymers as Drug Release Systems
James R. Smith
Pages 1-19
Electrospinning for Drug Delivery Applications
Luis Jesús Villarreal-Gómez, Graciela Lizeth Pérez-González
Pages 21-40
Melt Electrospinning and Electrowriting for Pharmaceutical and Biomedical Applications
María del Carmen De Lama-Odría, Luis J. del Valle, Jordi Puiggalí
Pages 41-70
Pharmaceutical Spray Drying
Ioannis Partheniadis, Nizar Al-Zoubi, Ioannis Nikolakakis
Pages 71-97
Vat Photopolymerisation Additive Manufacturing for Pharmaceutical Applications
Atheer Awad, Xiaoyan Xu, Jun Jie Ong, Alvaro Goyanes, Abdul W. Basit
Pages 99-124
Semi-solid Extrusion 3D Printing for the Development of Dosage Forms for Special Patient Groups
Angelos Gkaragkounis, Dimitrios G. Fatouros
Pages 125-136
Binder Jetting Powder Bed 3D Printing for the Fabrication of Drug Delivery System
Naseem A. Charoo, Eman M. Mohamed, Mathew Kuttolamadom, Mansoor A. Khan, Ziyaur Rahman
Pages 137-172
3D Printing for Localized Cancer Therapy
Mahmood Razzaghi, Amir Seyfoori, Mohsen Akbari
Pages 173-205
4D Printing in Pharmaceutics and Biomedical Applications
Moqaddaseh Afzali Naniz, Mohsen Askari, Ali Zolfagharian, Mahdi Bodaghi
Pages 207-247
Lithography in Drug Delivery
Khanh T. M. Tran, Thanh D. Nguyen
Pages 249-274
Micro-molding and Its Application to Drug Delivery
Edina Vranić
Pages 275-294
Supercritical Fluids: A Promising Technique in Pharmaceutics
Vivek Trivedi, Adejumoke Lara Ajiboye
Pages 295-320
Microfluidics as a Tool for the Synthesis of Advanced Drug Delivery Systems
João P. Martins, Hélder A. Santos
Pages 321-364
Nanofluidic Technologies for Drug Screening and Drug Delivery
Yutaka Kazoe, Kenji Sueyoshi, Sasikarn Seetasang, Yan Xu
Pages 365-418
Nanoparticles at the Stage of Clinical Trials
Konstantin Osetrov, Svetlana Morozkina, Petr Snetkov, Mayya Uspenskaya
Pages 419-428
Nasal Drug Delivery Systems for the Treatment of Diseases of the Central Nervous System and Tuberculosis
Thi Hong Nhung Vu, Svetlana Morozkina, Petr Snetkov, Mayya Uspenskaya
Pages 429-466
Regulatory Aspects and Barriers in Using Groundbreaking Technologies
Paola Minghetti, Umberto M. Musazzi, Paolo Rocco
Pages 467-491