Parkinson's Disease Molecular Mechanisms Underlying Pathology

Edited by Patrik Verstreken, VIB Center for the Biology of Disease, KU Leuven, Center for Human Genetics, Laboratory of Neuronal Communication, Leuven, Belgium   Features:

• Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology
• Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies
• Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease
• Includes approximately 25 color Illustrations and diagrams to explain concepts and models
• Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease

• List of Contributors
• Preface
• Chapter 1: The Neurogenetics of Parkinson’s Disease and Putative Links to Other Neurodegenerative Disorders
  • Abstract
  • 1. Introduction
  • 2. Definition of (Genetic) Parkinson’s Disease
  • 3. Classification and Nomenclature of Monogenic Parkinson’s Disease
  • 4. Monogenic Forms of Parkinson’s Disease and Parkinsonism
  • 5. PARK-SNCA
  • 6. PARK-LRRK2
  • 7. PARK-VPS35
  • 8. PARK-Parkin
  • 9. PARK-PINK1
  • 10. PARK-DJ-1
  • 11. Recent Novel Parkinson’s Disease Candidate Genes
  • 12. Systematic and Regularly Updated Overview of Parkinson’s Disease Mutations
  • 13. Reduced Penetrance and Variable Expressivity of Genetic Parkinson’s Disease
  • 14. Genetic Association Studies
  • 15. Candidate Gene Studies in Parkinson’s Disease
  • 16. Genome-Wide Association Studies
  • 17. Gene-Environment Interactions in Parkinson’s Disease
  • 18. Lessons Learned From Other Monogenic Neurodegenerative Diseases
  • 19. Translational Genetics: From Animal Models to Personalized Treatments
  • 20. Most Important Questions for Future Perspectives of PD Neurogenetics
• Chapter 2: Electron Transport Chain
  • Abstract
  • 1. Introduction
  • 2. Glycolysis in the Cytosol
  • 3. Impact of Electron Transport Chain Dysfunction on Neuronal Function
  • 4. What Have the Genetics Taught Us About Electron Transport Chain Dysfunction and the Sporadic Forms of Parkinson’s Disease?
  • 5. Correlation Between Findings Obtained Using Different Animal Models
  • 6. Therapeutic Pathways Targeting the Electron Transport Chain
  • 7. Conclusions
  • List of Abbreviations
• Chapter 3: Mitochondrial Fission and Fusion
  • Abstract
  • 1. Introduction
  • 2. Fission and Fusion Machinery
  • 3. Functions of Fission and Fusion in Neurons
  • 4. Fission and Fusion is Linked to Neurodegeneration
  • 5. PD Genes and Mitochondrial Morphology
  • 6. Mitochondrial Dynamics and Mitochondrial Turnover
  • 7. Therapeutic Potential of Targeting Fission and Fusion
  • 8. Conclusions
• Chapter 4: Axonal Mitochondrial Transport
  • Abstract
  • 1. Prelude
  • 2. On the Distribution of Power: Mitochondria to Match Supply and Demand
  • 3. Mitochondrial Movement is Essential for Maintaining a Healthy Mitochondrial Population in Neurons
  • 4. A Motor/Adaptor Complex Enables and Regulates Mitochondrial Trafficking
  • 5. Linking PD and Mitochondrial Transport: Mitochondrial Dysfunction Causes Mitochondrial Arrest
  • 6. Do Other Forms of PD Involve Defects in Mitochondrial Movement?
  • 7. Summary: The Virtuous and Vicious Cycles that Link Mitochondrial Transport and Mitochondrial Health
• Chapter 5: Mitophagy
  • Abstract
  • 1. Introduction
  • 2. Mitochondrial Quality Control
  • 3. PINK1 and Parkin
  • 4. PINK1-Parkin-Mediated Mitophagy
  • 5. PINK1 and/or Parkin-Independent Selective Mitophagy
  • 6. Methods to Detect Mitophagy
  • 7. Outstanding Questions
• Chapter 6: Autophagy
  • Abstract
  • 1. Introduction
  • 2. Lessons from the Genetics of Parkinsons Disease
  • 3. Ageing and Autophagy
  • 4. Autophagy in the Nervous System: Friend or Foe?
  • 5. Autophagy Induction to Promote Neuronal Survival
  • 6. Conclusions
• Chapter 7: Endocytosis and Synaptic Function
  • Abstract
  • 1. Introduction
  • 2. The Synaptic Vesicle Cycle and PD
  • 3. Exosome Release
  • 4. Summary
• Chapter 8: Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease
  • Abstract
  • 1. Introduction
  • 2. The Role of Glial Cells in PD
  • 3. Involvement of Proinflammatory Substances and Oxidative Stress in PD
  • 4. Infiltration of Lymphocytes in PD
  • 5. Involvement of PD-related Genes in Neuroinflammation
  • 6. Potential Antiinflammatory Treatments for PD
  • 7. Summary and Conclusions
  • Acknowledgments
• Chapter 9: Protein Translation in Parkinson’s Disease
  • Abstract
  • 1. Protein Translation and its Regulation in Neurons
  • 2. PD-Linked Mutations and Their Impact on Protein Translation
  • 3. Protein Translation and Neurotoxicity in Parkinson’s Disease
  • 4. Future Directions
  • Acknowledgments
• Index