Pharmaceutical Biotechnology

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.

Table of contents (25 chapters)

·         Molecular Biotechnology: From DNA Sequence to Therapeutic Protein

Oosting, Ronald S., Ph.D.

Pages 1-18

·         Biophysical and Biochemical Analysis of Recombinant Proteins

Arakawa, Tsutomu, Ph.D. (et al.)

Pages 19-45

·         Production and Purification of Recombinant Proteins

Kadir, Farida, Ph.D. (et al.)

Pages 47-67

·         Formulation of Biotech Products, Including Biopharmaceutical Considerations

Crommelin, Daan J. A., Ph.D.

Pages 69-99

·         Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics

Meibohm, Bernd, Ph.D., FCP

Pages 101-132

·         Immunogenicity of Therapeutic Proteins

Schellekens, Huub, Ph.D. (et al.)

Pages 133-141

·         Monoclonal Antibodies: From Structure to Therapeutic Application

Davis, John D., Ph.D. (et al.)

Pages 143-178

·         Genomics, Other “Omic” Technologies, Personalized Medicine, and Additional Biotechnology-Related Techniques

Sindelar, Robert D., Ph.D., FCAHS

Pages 179-221

·         Dispensing Biotechnology Products: Handling, Professional Education, and Product Information

Piascik, Peggy, Ph.D. (et al.)

Pages 223-235

·         Economic Considerations in Medical Biotechnology

Kolassa, Eugene M., Ph.D. (et al.)

Pages 237-245

·         Regulatory Framework for Biosimilars

Shah, Vinod P., Ph.D. (et al.)

Pages 247-254

·         Insulin

Beals, John M., Ph.D. (et al.)

Pages 255-275

·         Follicle-Stimulating Hormone

Sam, Tom, Ph.D. (et al.)

Pages 277-283

·         Human Growth Hormone

Dao, Le N. (et al.)

Pages 285-298

·         Recombinant Coagulation Factors and Thrombolytic Agents

Modi, Nishit B., Ph.D.

Pages 299-320

·         Recombinant Human Deoxyribonuclease I

Lazarus, Robert A., Ph.D. (et al.)

Pages 321-336

·         Monoclonal Antibodies in Cancer

Grimsley, Amy, PharmD (et al.)

Pages 337-359

·         Hematopoietic Growth Factors: Focus on Erythropoiesis-Stimulating Agents

Pérez-Ruixo, Juan Jose, Ph.D. (et al.)

Pages 361-374

·         Monoclonal Antibodies in Solid Organ Transplantation

Pilch, Nicole A., PharmD (et al.)

Pages 375-391

·         Monoclonal Antibodies and Antibody-Based Biotherapeutics in Inflammatory Diseases

Zhou, Honghui, Ph.D. (et al.)

Pages 393-412

·         Interferons and Interleukins

Ryff, Jean-Charles, M.D. (et al.)

Pages 413-437

·         Vaccines

Jiskoot, Wim, Ph.D. (et al.)

Pages 439-457

·         Oligonucleotides

Schiffelers, Raymond M., Ph.D. (et al.)

Pages 459-475

·         Gene Therapy

Wu, Hao, Ph.D. (et al.)

Pages 477-507

·         Stem Cell Technology

Pouton, Colin W., Ph.D.

Pages 509-524