Synopsis of Key Gynecologic Oncology Trials 1st Edition

This text is a fast and convenient overview of the clinical trials in gynecologic cancer treatment, setting out the evidence base of treatment decisions in uterine, ovarian, cervical and vulval cancers and gestational trophoblastic neoplasia. Residents and fellows will find this book an indispensable reference for revision, while existing practitioners will welcome it as a clarification of the evidence base for treatment options.

Table of Contents

1. Preface
2. Uterine Malignancies

Endometrial Carcinoma

Studies addressing surgical treatment

Lymph node assessment

Studies addressing adjuvant therapy

Radiation

Chemoradiation

Chemotherapy

Studies addressing treatment of recurrent endometrial carcinoma

Hormonal therapy

Chemotherapy

Targeted therapy

Immunotherapy

Uterine Carcinosarcoma

Studies addressing prognosticators

Studies addressing adjuvant treatment

Studies addressing treatment of advanced/ recurrent uterine carcinosarcoma

Uterine Leiomyosarcoma

Studies addressing adjuvant treatment of early stage uterine leiomyosarcoma

Studies addressing treatment of advanced uterine leiomyosarcoma

References

3. Ovarian Malignancies

Epithelial ovarian cancer (EOC)

Studies addressing upfront surgery

Studies addressing adjuvant therapy

Studies addressing neoadjuvant therapy

Studies addressing prediction of debulking

Studies addressing time point of treatment of recurrence

Studies addressing treatment of recurrent ovarian cancer, platinum-sensitive

Chemotherapy and targeted therapy

Secondary debulking surgery

Studies addressing treatment of recurrent ovarian cancer, platinum-resistant

Chemotherapy and targeted therapy

Immunotherapy

Mucinous epithelial ovarian cancer

Ovarian Germ Cell Tumors (GCT)

Ovarian Sex Cord-Stromal Tumors (SCT)

References

4. Cervical Cancer

Studies addressing surgical treatment

Studies addressing adjuvant therapy

Studies addressing primary chemoradiation therapy

Studies addressing treatment of recurrent or metastatic cervical cancer

Chemotherapy and targeted therapy

Immunotherapy

References

5. Vulvar Cancer

Studies addressing surgical treatment

Lymph node assessment

Studies addressing chemoradiation of advanced vulvar cancer

References

6. Gestational Trophoblastic Neoplasia (GTN)

Studies addressing surgical treatment

Studies addressing chemotherapy in low-risk GTN

Studies addressing (chemo)therapy in high-risk GTN

References

7. Glossary