The Rose and Mackay Textbook of Autoimmune Diseases, 7th Edition

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.

This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.

Table of contents

Section 1: Immunologic Basis of Autoimmunity

1. Prelude: Historical introduction to autoimmunity and autoimmune disease

2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity

3. General Features of Autoimmune Diseases (same title new contributor, new content)

4. Antigen Presentation, Dendritic Cells, and Autoimmunity

5. T cells and their subsets

6. Role of Th1 Th2 Th17 Cells in Autoimmunity

7. Tolerance and Autoimmunity: T Cells

8. Regulatory T Cells

9. B Cells and Autoimmunity

10. Immunological memory T cells

11. Immunological memory B cells

12. Apoptotic Cells as a Source of Autoantigens

13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes

14. Functional Effects of Autoantibodies

15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes

17. HLA Genetics and Autoimmunity

18. Non HLA Genetics

19. AIRE related Autoimmunity

20. Immune Deficiencies and Autoimmunity

21. Infections and Autoimmunity

22. Noninfectious Environmental Agents and Autoimmunity

23. Sex, Pregnancy and Autoimmunity

24. Animal Models of Autoimmune Disease

Section 2: Multisystem Diseases

25. Systemic Lupus Erythematosus

26. Systemic Sclerosis, Scleroderma

27. Antiphospholipid Syndrom

28. Sjogren Syndrome

29. Rheumatoid Arthritis

30. Spondyloarthritis and Chronic Idiopathic Arthropathies

31. Myositis

32. Thyroid Disease

33. Type 1 Diabetes

34. Adrenalitis

35. Polyendocrine Syndromes

36. Gastritis and Pernicious Anemia

37. Hypophysitis

38. Hemolytic Anemia

39. Thrombocytopenic Purpura

40. Neutropenia

41. Aplastic Anemia

42. Clotting Disorders

43. Multiple Sclerosis

44. Peripheral Neuropathy

45. Myasthenia Gravis

46. Ocular Disease

47. Inner Ear Disease

48. Celiac Disease

49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease

50. Chronic Hepatitis

51. Primary Billiary Cirrhosis

52. Primary Sclerosing Cholangitis

53. Pancreatitis

54. Bullous Skin Diseases: Pemphigus and Pemphigoid

55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria

56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis

57. Orchitis and Male Infertility

58. Oophoritis

59. Rheumatic Heart Disease

60. Myocarditis and Dilated Cardiomyopathy

61. Necrotizing Arteritis and Small Vessel Vasculitis

62. Large and Medium Vessel Vasculitides

63. Autoimmune Disorders of the Lung

64. Paraneoplastic Diseases

65. Antibody-Associated Neurological Diseases

66. Autoinflammatory and other Related Diseases

67. Autoinflammatory diseases and autoimmune responses to tumors

68. COVID

Section 3: Diagnosis, Prevention, and Therapy

69. Autoantibody Assays, Testing, and Standardization

70. Prediction of Autoimmune Disease

71. Emerging Therapies for Autoimmune Diseases

72. Postlude