Viral Drug Delivery Systems: Advances in Treatment of Infectious Diseases

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity.

A total of four books are covered under the series of Infectious drug diseases.

- Malarial drug delivery systems

- Tubercular drug delivery systems

- Viral drug delivery systems

- Infectious disease drug delivery systems

The third volume of series is focused on viral drug delivery systems. Typically, virus attaches to the cells (referred as host cell) and releases its DNA or RNA inside the cell. In second stage, virus’s genetic material takes control of the cell and forces it to replicate the virus leading to onset of disease symptoms. DNA class of viruses include Herpes, Papilloma and Adeno viruses. RNA class of viruses include retroviruses, such as HIV immunodeficiency virus and SARS COV – 2 / Corona virus. This book addresses recent developments in viral drug delivery systems. It covers many different aspects of viral infections, ways to treat them using modern drug delivery systems like nano particulate carriers. The choice of viral delivery systems mainly depends upon the type of virus, duration of life cycle, presence of drug resistance, cellular and mucosal interaction of virus, accordingly gene or non-gene drug delivery systems are selected. Besides that, this book also reports global dynamics of viral diseases, future predictions of infection rate, current treatment options, details of drug carriers like nanoemulsions, polymeric nanoparticles, role of biofunctionalization, and phyto-molecules in treatment of viral infections particularly herpes, Covid-19, Ebola, HIV/AIDS, influenza and viral hepatitis.

Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of viral drug delivery research.

Table of contents

Front Matter
Pages i-x
​​​​​​​Global Health and Viral Diseases: Past, Present, and Future
Sarika Chauhan, Surya Sankineni, Ranjita Shegokar, Yashwant Pathak
Pages 1-16
Drug Resistance in Antiviral Therapy
Seth Kwabena Amponsah, Benjamin Tagoe
Pages 17-26
Viral Diseases: Cellular Understanding of Diseases
Adithya Kaushal, Divya Kaushal, Ranjita Shegokar, Yashwant Pathak
Pages 27-63
Viral Infections: Current Treatment Options
Sagar Salave, Dhwani Rana, Arti Bodar, Dignesh Khunt, Bhupendra Prajapati, Jayvadan Patel
Pages 65-89
Mucosal Targeting Strategies for Antiviral Drug Delivery
Tayo Alex Adekiya, Mumuni Sumaila, Raphael Taiwo Aruleba, Yahya E. Choonara
Pages 91-117
Micro- and Nanoemulsions in Antiviral Treatment
Nidhi Mishra, Neelu Singh, Poonam Parashar
Pages 119-139
Novel Formulation Approaches for Treatment of Ebola Virus
Sankha Bhattacharya, Shambhavi Singh, Sambuddha Chakraborty, Bhupendra G. Prajapati, Mahavir Chougule, Jayvadan K. Patel
Pages 141-160
Drug Delivery Options for Treatment of Ebola Infection
Harshita Krishnatreyya, Hemanga Hazarika, Bhrigu Kumar Das, Neelutpal Gogoi, Abdul Baquee Ahmed, Kamaruz Zaman
Pages 161-191
Polymers for Biosensing Applications in Viral Detection and Diagnosis
Kavyashree Puttananjegowda, Arash Takshi, Sylvia Thomas
Pages 193-217
Nanotechnology: A Stepping Stone Toward Viral Hepatitis Treatment and Prevention in Children and Adults
Kshama Patel, Yash Pagarani, Ranjita Shegokar, Yashwant Pathak
Pages 219-235
Recent Developments in the Treatment of Influenza
Lachlan Shiver, Caroline Ward, Brian Arciola, Evan Adler, Charles Preuss
Pages 237-267
COVID-19: Molecular Pathogenesis and Prospective Therapeutic Interventions
Priya Shrivastava, Suresh P. Vyas
Pages 269-294
Nano-Drug Delivery Systems for COVID-19 Drug Delivery
Komal Parmar, Jayvadan Patel
Pages 295-309
Exploring the Link Between Malaria and COVID-19
Orhan E. Arslan
Pages 311-338
The Use of Azithromycin and Lopinavir-Ritonavir in the Treatment of COVID-19
Andang Miatmoko, Yulistiani, Melanny Ika Sulistyowati, Dwi Setyawan, Devy Maulidya Cahyani, Purwati
Pages 339-360
Current Strategies to Combat COVID-19
Vidhi Shah, Tejal Mehta
Pages 361-374
Phytomolecules and Novel Drug Delivery Approach for COVID-19
Mittal Maheshwari, Bharat Patel, Niyati Acharya
Pages 375-405
Back Matter
Pages 407-409