Nanotechnology Methods for Neurological Diseases and Brain Tumors

Drug Delivery across the Blood–Brain Barrier
Edited by Yasemin Gürsoy Özdemir, Koç University, Istanbul, Turkey; Sibel Bozdag Pehlivan, Hacettepe University, Ankara, Turkey and Emine Sekerdag, Ko? University, Istanbul, Turkey   Features:

• Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases
• Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier
• Written in a language that makes it easy to understand nanotechnology drug delivery techniques
• Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors

Table Of Contents: 1. The rationale to reach the brain
1.1. Anatomy and physiology of the BBB
1.2. Drug transport and drug metabolism at BBB
1.2.1. Genomics and proteomics of BBB
1.2.2. Transporter systems of BBB and microdialysis
1.2.3. PK/PD in brain drug delivery
2. Nose-to-brain drug delivery
2.1. Nasal physiology and drug administration
2.2. Challenges of the noise-to-brain route
3. Nanoscience in targeted brain drug delivery
3.1. Importance and application of nanotechnology-based brain drug delivery
3.1.1. Nanoparticles
3.1.2. Liposomes
3.1.3. Dendrimers
3.1.4. Carbon nanotubes
3.2. Neurotoxicity
3.3. Clinical considerations 
3.4. Ethical and regulatory issues
4. Brain targeted experimental models
4.1. In vitro CNS models
4.2. In vivo and in situ animal models
4.3. PET
5. Targeted treatment strategies for neurological diseases
5.1. Alzheimer’s Disease
5.2. Parkinson’s Disease
5.3. Stroke
6. CNS tumor targeting
 Future outlook