Pharmaceutical Dosage Forms: Tablets, 3e, Vol1 -Unit Operations and Mechanical Properties

Pharmaceutical Dosage Forms: Tablets, Third Edition is a comprehensive treatment of the design, formulation, manufacture, and evaluation of the tablet dosage form. The ultimate goal of drug product development is to design a system that maximizes the therapeutic potential of the drug substance and facilitates its access to patients; Volume One focuses unit operations and mechanical properties.This reference examines the fundamental physical and chemical processes that the different unit operations use, and then applies this knowledge to the discussion of the varying unit operations and processes.

Table of Contents

1. Principles of Sampling for Particulate Solids. 2. Particle and Powder Bed Properties. 3. Flow: General Principles of Bulk Solids Handling. 4. Blending and Blend Uniformity. 5. Milling. 6. Drying. 7. Spray Drying: Theory and Pharmaceutical Applications. 8. Pharmaceutical Granulation Processes, Mechanism, and the Use of Binders. 9. Dry Granulation. 10. The Preparation of Pellets by Extrusion/Spheronization. Coating Processes and Equipment. 12. Aqueous Polymeric Film Coating. 13. The Application of Thermal Analysis to Pharmaceutical Dosage Forms. 14. Preformulation Studies for Tablet Formulation Development. 15. Stability Kinetics. 16. Compaction Simulation
17. Compression and Compaction.