Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12

• Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field
• Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients
• Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

1. Introductory Chapter
2. Tumor Metabolic Reprogramming in Therapeutic Resistance
3. Development of novel antiandrogens to overcome castrate resistant prostate cancer
4. Microenvironmental regulation of cancer response to therapy and therapy resistance
5. Revisiting immunogenic cell death to overcome treatment resistance in cancer immunotherapy
6. Preventing Phenotypic Plasticity in Cancer to Mitigate Therapy Resistance
7. Overcoming drug resistance in cancer with targeted radionuclide therapy
8. The PI3K pathway and chemotherapy resistance
9. Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia
10. Escape from apoptosis: Anastasis as a potential mechanism of cancer drug resistance
11. From genetic data and structures to drug development: new approaches to targeting Eph receptors
12. Overcoming Therapeutic Resistance in Glioblastoma: a major clinical challenge