A European Multidisciplinary Textbook

Editors: Wyld, L., Markopoulos, C., Leidenius, M., Senkus-Konefka, E. (Eds.)

Provides an evidence-based discussion, citing the most recent literature
Closely linked to European practice guidelines (EUSOMA, St. Gallen, ESMO)
Contains clinical algorithms for case management in each section to serve as a ready reference
Includes a selection of top European opinion leaders as section authors
Published with the official approval of European Society of Surgical Oncology and EUSOMA
Contains a selection of self-test MCQs
Ideal reference book for the preparation of any European exam in Breast Surgery

This textbook provides a comprehensive overview of the state of the art knowledge of breast cancer management for the modern breast surgeon. It covers all aspects of multidisciplinary care including primary breast and axillary surgery, reconstruction and oncoplastic techniques, external beam radiotherapy and newer techniques such as tomotherapy, intraoperative radiotherapy and brachytherapy. In addition, systemic therapies including chemotherapy, the latest biological targeted therapies and endocrine therapies are covered. Readers can find out about other important aspects of breast cancer such as genetics, screening, imaging and long-term health among others.

Chapters take the reader through the basics up to the highest levels of knowledge in an easy to understand format with management algorithms to aid clinical care, generous referencing of the best literature and figures and photographs to illustrate each section.

Published with the official approval of the European Society of Surgical Oncology (ESSO) and the European Society of Breast Cancer Specialists (EUSOMA), the book is written by a panel of recognised leaders in the field and is an indispensable guide for the practicing breast specialist and senior specialists in training, wishing to update their knowledge with the latest trends or polish off their training before accreditation.

Lynda Wyld is Reader in Surgery at the University of Sheffield and Consultant Oncoplastic Breast Surgeon at Doncaster and Bassetlaw Teaching Hospital in the UK. She is the secretary of the Division of Breast Surgery of the UEMS section of surgery, current President of the British Association for Surgical Oncology (BASO), Chair of the Education and Training Committee of the European Society for Surgical Oncology (ESSO) and member of the executive board of the European Society of Breast Cancer Specialists (EUSOMA). She has published over 70 papers in peer reviewed journals and 10 book chapters.

Christos Markopoulos is Professor of Surgery at the Faculty of Medicine of the National and Kapodistrian University of Athens in Greece and Head of the Breast Unit. He is the President of the Division of Breast Surgery of UEMS Section of Surgery and the founder and Chair of the Hellenic Society of Breast Surgeons (2000-2015). He is an active member of multiple Breast International Societies, including British Association of Breast Surgery (ABS) and European Society of Surgical Oncology (ESSO) and member of the Executive Committee of the European Society of Breast Cancer Specialists (EUSOMA).

Professor Markopoulos has published over 300 scientific papers in peer reviewed national and international medical journals having over 4,000 citations and has also authored several books on the management of breast disease.

Marjut Leidenius is the Department Head of the Breast Surgery Unit in Comprehensive Cancer Center, Helsinki University Hospital, Finland. She has been active in national and international societies such as the Finnish Society of Surgery, ESSO (European Society of Surgical Oncology) and EUSOMA (European Society for Breast Specialists). She is currently the ESSO Honorary Secretary and EUSOMA Board member. She has also been the Chair of the Breast Surgery Division in UEMS Section of Surgery from 2009 to 2016.

Marjut Leidenius has published more than 100 original research and review articles in peer reviewed national and international journals. She is also the Associate Editor for Breast Cancer in European Journal of Surgical Oncology (EJSO).

Elżbieta Senkus-Konefka is a senior lecturer at the Department of Oncology and Radiotherapy, Medical University of Gdańsk, Her main scientific interest in breast cancer is the molecular basis of disease in high-risk patients. She is involved in developing international guidelines for early and metastatic breast cancer on behalf of the European Society for Medical Oncology (ESMO) and the European School of Oncology (ESO) and is an ESMO Faculty Member for Breast Cancer.

Elżbieta Senkus-Konefka serves as a Specialty Editor for “The Breast” journal and is actively involved in undergraduate and postgraduate teaching, including courses organized by the European Society for Therapeutic Radiology and Oncology (ESTRO) and ESO. She is a member of the ESMO, ESTRO, the European Society of Breast Cancer Specialists (EUSOMA) and of Mensa International. She has contributed to over 100 peer-reviewed publications, fifteen book chapters and was an editor of a textbook.

Table of contents (43 chapters)

Gross Anatomy of the Breast and Axilla

Palhazi, Peter, MD

Pages 3-10
Physiology and Developmental Stages of the Breast

Troupis, Theodore G. (et al.)

Pages 11-17
Breast Cancer Epidemiology

Parks, R. M., BMBS (et al.)

Pages 19-29
Effect of Oestrogen Exposure, Obesity, Exercise and Diet on Breast Cancer Risk

Petridou, Eleni Th., MD, MPH, PhD (et al.)

Pages 31-42
Hereditary Breast Cancer Genetics and Risk Prediction Techniques

Carley, Helena, MBChB(Hons) BSc(Hons) (et al.)

Pages 43-56

Screening for High-Familial-Risk Women

Vourtsis, Athina, MD, PhD

Pages 59-67
Risk-Reducing Breast and Ovarian Surgery for Women at High Familial Risk

Schultz, Inkeri, MD, PhD (et al.)

Pages 69-78
The Role of Breast Cancer Chemoprevention in High-Risk Women

Wyld, Lynda, MB, ChB, PhD, FRCS

Pages 79-87
Molecular Profiling of Breast Cancer and DCIS

Markopoulos, Christos, MD, PhD

Pages 89-101
Pathology of High-Risk Breast Lesions

Pinder, Sarah E., FRCPath (et al.)

Pages 103-114
Ductal Carcinoma in Situ

Carter, Stacey A., MD (et al.)

Pages 115-126
Imaging of the Breast

Steyerova, Petra, MD

Pages 127-145
Breast Cancer Screening

Mathew, John, DM, FRCS (et al.)

Pages 147-156
Clinical Presentation, Diagnosis and Staging of Breast Cancer

Zgajnar, Janez, MD, PhD

Pages 159-176
Pathology of Breast Cancer

Penault-Llorca, Frederique, MD, PhD (et al.)

Pages 177-191
The Breast and Oncoplastic Multidisciplinary Team

MacNeill, Fiona, MD, MBBS, FRCS (et al.)

Pages 193-202
Surgery to the Breast: Mastectomy

Charalampoudis, Petros, MD, FRCS, FEBS (et al.)

Pages 203-211
Surgery to the Breast: Breast Conservation Techniques

Leidenius, Marjut, MD, PhD

Pages 213-227
Oncoplastic Breast-Conserving Therapy

Sanidas, Elias E., MD, FACS (et al.)

Pages 229-244
Fat Transfer in Oncoplastic and Reconstructive Breast Surgery

Bonomi, Riccardo (et al.)

Pages 245-253
Breast Surgery after Primary Systemic Treatment

Kuehn, Thorsten, MD

Pages 255-262
Surgery for Locally Recurrent Breast Cancer

Agresti, Roberto, MD (et al.)

Pages 263-273
Management of the Axilla: Sentinel Lymph Node Biopsy

Bergkvist, Leif, MD, PhD (et al.)

Pages 275-284
Axillary Node Clearance

Meretoja, Tuomo J., MD, PhD

Pages 285-290
Axillary Management in the Neoadjuvant Setting

Wimmer, K. (et al.)

Pages 291-301

Axillary Reverse Mapping: ARM

Rubio, Isabel T., MD (et al.)

Pages 303-312
Immediate Reconstruction: General and Oncological Considerations

Cardoso, Maria João, MD, PhD (et al.)

Pages 315-323
Delayed Breast Reconstruction: General and Oncological Considerations

Mátrai, Zoltán, MD, PhD, FEBS

Pages 325-353
Breast Implants: Design, Safety and Indications for Use

Boniface, Jana, MD, PhD (et al.)

Pages 355-364
Specific Implant-Based Techniques for Breast Reconstruction

Cook, Lorna J., BA, MBBS, FRCS (et al.)

Pages 365-379
Specific Autologous Flap Techniques

Suominen, Sinikka, MD, PhD (et al.)

Pages 381-392
Goldilocks Procedure

MacNeill, Fiona, MBBS, FRCS, MD, FEBS

Pages 393-400
Nipple Reconstruction

Lefemine, Valentina (et al.)

Pages 401-410
Complications of Breast Surgery and Their Management

Kontos, Michalis, MD, PhD (et al.)

Pages 411-423
Adjuvant Endocrine Therapy

Rabaglio, Manuela, MD (et al.)

Pages 427-438
Adjuvant Chemotherapy

Curigliano, Giuseppe, MD, PhD (et al.)

Pages 439-445
Adjuvant Molecular Therapies in Breast Cancer

Prove, A. (et al.)

Pages 447-452
Primary Systemic Therapy for Breast Cancer

Liedtke, Cornelia, MD PhD (et al.)

Pages 453-462
Radiotherapy for Breast Cancer

Jereczek-Fossa, Barbara Alicja, MD, PhD (et al.)

Pages 463-483
Breast Cancer in Special Groups: Young Women with Early Breast Cancer

Graffeo, Rossella, MD (et al.)

Pages 487-498
Hereditary Breast Cancer

Ramón y Cajal, Teresa, MD, PhD (et al.)

Pages 499-510
Breast Cancer in Special Groups: Breast Cancer in Pregnancy

Lambertini, Matteo, MD (et al.)

Pages 511-520
Fertility Preservation in Women with Breast Cancer

Mislang, Anna Rachelle, MD (et al.)

Pages 521-527