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Intracytoplasmic Sperm Injection Indications, Techniques and Applications

Intracytoplasmic Sperm Injection Indications, Techniques and Applications
Intracytoplasmic Sperm Injection Indications, Techniques and Applications
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Introduction

This unique, comprehensive text on the male factor infertility experience centers on the current background, applications and techniques for intracytoplasmic sperm injection (ICSI), one of the more commonly utilized procedures in modern assisted reproduction for male infertility, offering insights into the rationale and indications for ICSI and providing an up-to-date discussion on male factor diagnostic tests and microsurgical techniques for ICSI itself. Topics covered include the role of reproductive genetics, the effects of paternal age, the assessment, development and selection of functional human spermatozoa (e.g., Comet assay), both naturally and in the laboratory, and the procedures by which these sperm are injected directly into an oocyte. Comparisons are made between efficacy rates of ICSI versus conventional IVF strategies, and clinical approaches to fertilization failures following ICSI are presented, and intracytoplasmic morphologically selected sperm injection (IMSI) is discussed in detail in a chapter of its own.

Bringing together the latest evidence and written by international leaders in the field, Intracytoplasmic Sperm Injection: Indications, Techniques and Applications is a unique and accessible resource for reproductive endocrinologists, andrologists, geneticists and infertility practitioners and researchers alike.


Keywords

Assisted reproductive technologies (ART) Azoospermia Cryptozoopermia Comet assay Infertility Intracytoplasmic morphologically selected sperm injection (IMSI) Intracytoplasmic sperm injection (ICSI) In vitro fertilization (IVF) In vitro spermatogenesis Male factor infertility Oligozoospermia Reproductive genetics Sperm DNA integrity Sperm morphology analysis Sperm retrieval methods Spermatogenic dysfunction Spermatozoa Testicular sperm extraction (TESE) andrology


  1. Front Matter
    Pages i-xiii
  2. Male-Factor Infertility: Factoring in the Male Experience
    Diederik F. Janssen
    Pages 1-8
  3. Intracytoplasmic Sperm Injection: History, Indications, Technique, and Safety
    Nigel Pereira, Gianpiero D. Palermo
    Pages 9-21
  4. The Role of Reproductive Genetics in Modern Andrology
    Douglas T. Carrell, Timothy G. Jenkins, Benjamin R. Emery, James M. Hotaling, Kenneth I. Aston
    Pages 23-38
  5. Effect of Paternal Age on Reproductive Outcomes: Data from Intracytoplasmic Sperm Injection and Oocyte Donation
    Lena Sagi-Dain, Martha Dirnfeld
    Pages 39-47
  6. New Paradigms in De Novo Creation of Functional Human Spermatozoa: A Review of Biological Progress Towards Clinical Application
    Nina Neuhaus, Tim Pock, Stefan Schlatt, Verena Nordhoff
    Pages 49-61
  7. Assessment of Sperm DNA Integrity and Implications for the Outcome of ICSI Treatments
    Preben Christensen, Anders Birck
    Pages 63-84
  8. Sperm Evaluation Using the Comet Assay
    Océane Albert, Bernard Robaire
    Pages 85-98
  9. Automated Morphology Detection from Human Sperm Images
    Seyed Abolghasem Mirroshandel, Fatemeh Ghasemian
    Pages 99-122
  10. Clinical Approaches to Male Factor Infertility
    Omer A. Raheem, Tung-Chin Hsieh
    Pages 123-141
  11. Intracytoplasmic Morphologically Selected Sperm Injection (IMSI): An Overview
    Daniel Luna Origgi, Javier García-Ferreyra
    Pages 143-155
  12. Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods
    Nikita Abhyankar, Samuel Ohlander, Martin Kathrins
    Pages 157-168
  13. Intracytoplasmic Sperm Injection (ICSI): Applications and Insights
    Toru Suzuki, Anthony C. F. Perry
    Pages 169-181
  14. The Human Y-chromosome: Evolutionary Directions and Implications for the Future of “Maleness”
    Darren K. Griffin, Peter J. I. Ellis
    Pages 183-192
  15. Back Matter
    Pages 193-198



About the editors

Gianpiero D. Palermo, MD, PhD, Director of Assisted Fertility and Andrology, Blavatnik Distinguished Professor of Reproductive Medicine, Professor of Embryology in Obstetrics and Gynecology, Center for Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA

E. Scott Sills, MD, PhD, Medical Director, Center for Advanced Genetics, Reproductive Research Section, San Clemente, CA, USA

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Ετικέτες: Urology , Andrology