CAR-T Manufacturing Technologies and Innovations

This edited volume describes innovations in all steps of the CAR-T manufacturing chain. These vital descriptions will help practitioners to overcome current challenges during the process and vastly reduce costs and enable timely and accessible administration of CAR-T therapy to patients.

The book provides readers with information on key fundamental concepts of CAR-T manufacturing in areas such as cell selection, cell activation, cell transfection, cell expansion, genetic engineering, and quality control. In each chapter, different experts cover a particular technological field in the CAR-T manufacturing chain. Each chapter will include an introduction to the importance of a particular technology for cell manufacturing, comparisons of state-of-the-art methods, and discussions on emerging innovations of that particular technology. This exposes readers to a high-level view of the entire process while diving into details for each specific process step. Readers will be able to apply their knowledge to make changes at each step of the CAR-T manufacturing process to reduce the currently high costs and long production times, so that cancer patients globally can benefit from CAR-T therapy.

This book is an invaluable resource for practitioners in CAR-T manufacturing who aim to improve their quality and efficiency while reducing time and costs. It is also useful for advanced undergraduate and graduate students who wish to gain a strong foundation for continuing research in the field or interacting with practitioners.

CONTENTS

1. Immune cell selection and Isolation Jessalyn Low, Andy Tay  2. Strategies for T cell Activation Jessalyn Low, Andy Tay  3. Genetic tools to engineer CAR-T cells: Lessons from clinical studies Yu Yang Ng, Andy Tay  4. Intracellular delivery methods for therapeutic immune T-cell engineering Arun R. K. Kumar, Andy Tay  5. Bioreactor technology for CAR T cell manufacturing Yi Kai Luo, Andy Tay  6. Quality Control of CAR-T Products Jerome Adriel Tjiptadi, Andy Tay  7. Advances for in vivo CAR-T manufacturing Mohamed Bilal S/O Saibudeen, Kenneth Goh Jun Lim, Andy Tay