Cholesterol From Chemistry and Biophysics to the Clinic

• Ties basic biology to clinical application and drug discovery
• Provides methods and protocols for lab-based cholesterol research and clinical testing
• Examines the latest pharmacological discoveries employed to tackle cholesterol related disorders
• Includes chapter contributions from a wide range of specialists, uniting various disciplines

Part 1. Cholesterol Chemistry and Cell Function

1. Cholesterol chemistry, and laboratory synthesis
Hélio M.T. Albuquerque, Clementina M.M. Santos, and Artur M.S. Silva

2. Molecular evolution of cholesterol and other higher sterols in relation to membrane structure
Ole G. Mouritsen

3. Role of cholesterol in maintaining the physical properties of the plasma membrane
Witold K. Subczynski, Marta Pasenkiewicz-Gierula, Justyna Widomska, and Natalia Stein

4. The fundamental interaction of cholesterol with lipid membranes: The umbrella model
Juyang Huang

5. Model peptides and cholesterol
István P. Sugár and Parkson Lee-Gau Chong

6. Cholesterol and ceramide: An unlikely pair
Aritz B. García-Arribas, Alicia Alonso, and Félix M. Goñi

7. Cholesterol-recognizing amino acid consensus motifs in transmembrane proteins: Comparative analysis of in silico studies and structural data
Fodil Azzaz, Henri Chahinian, Nouara Yahi, Coralie Di Scala, Carlos J. Baier, Francisco J. Barrantes, and Jacques Fantini

8. Effects of cholesterol on the GPCR AT1 receptor and its interplay with AT1 antagonists
S. Kiriakidi, Z. Cournia, and T. Mavromoustakos

9. Principles of cholesterol regulation of ion channels
Qiu-Xing Jiang and Irena Levitan

10. Fluorescent probes for microscopy visualization of cholesterol topography and dynamics in membranes
Francisco J. Barrantes

11. Cholesterol transport in blood, lipoproteins, and cholesterol metabolism
Mark T Mc Auley and Amy E Morgan

12. Common laboratory research methods for detection and quantification of cholesterol
Anna N. Bukiya, Hanxuan Li, Steven Mysiewicz, and Wei Li

Part 2. Cholesterol Homeostasis and its disruption

14. Diet-induced hypercholesterolemia in small laboratory animal models
Tina Herfel

15. Nutrition and cholesterol metabolism
Ghada A. Soliman

16. Cholesterol and early development
Isabella Ellinger and Waranya Chatuphonprasert

17. Clinical and biochemical diagnostic methods: What do blood lipid levels tell us?
Marshall B. Elam

18. Familial hypobetalipoproteinemia and abetalipoproteinemia
Francine K. Welty

19. Critical illness and cholesterol levels
Zdenek Zadak

20. Familial hypercholesterolemia
Shifa Jebari-Benslaiman, Unai Galicia-Garcia, Asier Larrea-Sebal, Kepa B. Uribe, Cesar Martin, and Asier Benito-Vicente

21. Niemann-Pic type C disease (NPC)
Agnieszka Lugowska

22. Rare monogenic disorders of cholesterol metabolism
Malgorzata Bednarska-Makaruk and Agnieszka Lugowska

23. Secondary (acquired) hypercholesterolemia
Arrigo F.G. Cicero and Ivan R. Cincione

24. Blood lipids and molecular pathways of atherogenesis
Ricardo Stein, Filipe Ferrari, and Vítor M. Martins

25. Lysosomal acid lipase: Roles in rare deficiency diseases, myeloid cell biology, innate immunity, and common neutral lipid diseases
Gregory A. Grabowski and Hong Du

26. Cholesterol and pathogens
Tatiana M. Clemente and Stacey D. Gilk

27. Involvement of cholesterol and ß-amyloid in the initiation and progression of Alzheimer’s disease
Luis G. Aguayo, Jorge P. Roa, Carlos F. Burgos, and Juliana  Gonzalez-Sanmiguel

28. Cholesterol and alcohol
Andrew S. Bell, Emma M. O’Connell, and Falk W. Lohoff

Part 3. Pharmacological Considerations and Perspectives

29. Cholesterol stiffening of lipid membranes and drug interactions: Insights from neutron spin echo and deuterium NMR spectroscopy
Sudipta Gupta, Fathima T. Doole, Teshani Kumarage, Milka Doktorova, George Khelashvili, Rana Ashkar, and Michael F. Brown

30. Cholesterol in drug delivery systems
DanRong Hu and ZhiYong Qian

31. Modification of vascular receptor pharmacology by cholesterol: From molecular determinants to impact on arterial function
Alex M. Dopico, Anna N. Bukiya, and Kelsey C. North

32. Clinical strategies for reducing cholesterol levels
Claude K. Lardinois and Samantha Karr

33. Medicinal chemistry and pharmacology of statins
Bob M. Moore, II and George A. Cook

34. Cyclodextrins as promising therapeutics against cholesterol overload
Florina Zakany, Tamas Kovacs, Lajos Szente, and Zoltan Varga

35. Hyperlipidemia and rheumatoid arthritis
Aliki I. Venetsanopoulou, Paraskevi V. Voulgari, and Alexandros A. Drosos

36. Management of hypercholesterolemia in individuals living with HIV/AIDS
Musaab Ahmed, Marium Ahmed, Dushyant Mital, and Mohamed H Ahmed

Edited by Anna N. Bukiya, Professor, Department of Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA and Alex M. Dopico, Van Vleet Chair of Excellence, Dept. Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA