Contemporary Management of Acute Lymphoblastic Leukemia

 Acute lymphocytic leukaemia (ALL) is a fast-growing cancer of a type of white blood cells called lymphocytes. These cells are found in the bone marrow and other parts of the body (MedlinePlus).

This book is a comprehensive guide to the management of Acute Lymphoblastic Leukaemia. Beginning with an introduction to the disease, its history and epidemiology, the next sections discuss diagnosis, classification, molecular pathogenesis, and cytogenetics.

The following chapters examine different treatment methods, with in depth discussion on chemotherapy and a chapter dedicated to stem cell transplantation.

Written by an experienced specialist from City of Hope National Medical Centre, California, this practical manual includes more than 50 images, illustrations and tables to enhance learning.

 

Key points

• Comprehensive guide to management of Acute Lymphoblastic Leukaemia
• In depth coverage of chemotherapy
• Includes chapter on stem cell transplantation
• Authored by experienced specialist from City of Hope National Medical Centre, California
• • CHAPTER 1
  • Treatment of Acute Lymphoblastic Leukemia: A Historical Perspective 1
  • Vinod Pullarkat
  • CHAPTER 2
  • Epidemiology and Etiology of Acute Lymphoblastic Leukemia 10
  • Amie E Hwang, Kevin Y Urayama, Roberta McKean-Cowdin, Wendy Cozen
  • CHAPTER 3
  • Diagnosis and Classification of Acute Lymphoblastic Leukemia 49
  • Anna K Wong, Sheeja T Pullarkat
  • CHAPTER 4
  • Molecular Pathogenesis of Acute Lymphoblastic Leukemia 67
  • Enzi Jiang, Cynthia Hinh, Sajad Khazal, Yong-Mi Kim
  • CHAPTER 5
  • Cytogenetics of Acute Lymphoblastic Leukemia 88
  • Marilyn L Slovak
  • CHAPTER 6
  • Chemotherapy of Childhood Acute Lymphoblastic Leukemia 129
  • Kristen Eisenman, Ashley Rogers, Stephen P Hunger
  • CHAPTER 7
  • Chemotherapy of Adult Acute Lymphoblastic Leukemia 149
  • Ibrahim Aldoss, Vinod Pullarkat
  • PRELIMS_.indd 5 07-04-2014 10:48:14vi Acute Lymphoblastic Leukemia
  • CHAPTER 8
  • Use of Asparaginase in Acute Lymphoblastic Leukemia Therapy 173
  • Patrick W Burke, Justin M Watts, Martin S Tallman, Dan Douer
  • CHAPTER 9
  • Monitoring of Minimal Residual Disease to Guide Therapy of 
  • Acute Lymphoblastic Leukemia 200
  • Allen EJ Yeoh, Dario Campana
  • CHAPTER 10
  • Prophylaxis and Treatment of CNS Involvement in 
  • Acute Lymphoblastic Leukemia 218
  • Rebecca L Olin, Lloyd E Damon
  • CHAPTER 11
  • Pharmacogenomics of Acute Lymphoblastic Leukemia Chemotherapy 246
  • Stéphanie Dulucq, Maja Krajinovic
  • CHAPTER 12
  • Hematopoietic Stem Cell Transplantation for 
  • Acute Lymphoblastic Leukemia 276
  • Sandra H Thomas, Stephen J Forman
  • CHAPTER 13
  • Late Effects of Acute Lymphoblastic Leukemia Therapy 295
  • Preeti Chaudhary, Vinod Pullarkat
  • CHAPTER 14
  • Novel Agents for the Treatment of Acute Lymphoblastic Leukemia 318
  • Justin M Watts, Patrick W Burke, Dan Douer, Martin S Tallman