Design and Manufacture of Pharmaceutical Tablets

Features:

• Incorporates important mathematical models and computational applications
• Includes unique content on central composite design and augmented simplex lattice
• Provides background on important design principles with emphasis on quality-based design (QBD) of pharmaceutical dosage forms

Table Of Contents:

• Dedication
• Preface
• Abbreviations
• Chapter One: Introduction
  • Abstract
  • 1.1. General considerations [1, 2]
  • 1.2. Particle sizes [3]
  • 1.3. Excipients [4]
  • 1.4. Equipment
  • 1.5. Mixing of pharmaceutical powders [5]
  • 1.6. Design of experiments [6–9]
• Chapter Two: Conventional-Release (CR) Tablets
  • Abstract
  • 2.1. Low-dose tablet by direct compression (DC)
  • 2.2. High-dose tablet by direct compression
  • 2.3. Low-solubility API, low-dose tablet by wet granulation (WG) [1]
  • 2.4. Soluble API, low-dose tablet by wet granulation
  • 2.5. Low-solubility API, high-dose tablet by wet granulation
  • 2.6. Soluble API, high-dose tablet by wet granulation [2]
• Chapter Three: Slow-Release (SR) Tablets
  • Abstract
  • 3.1. Slow-release tablet using a lipophilic release control agent
  • 3.2. Slow-release tablet using Eudragit and Methocel as release control agents
  • 3.3. Slow-release tablet using a mixture of Methocels as release control agent [1]