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Drug Delivery Systems, Third Edition

Drug Delivery Systems, Third Edition
Drug Delivery Systems, Third Edition
  • Συγγραφείς: Vasant V. Ranade ,  John B. Cannon
  • ISBN: 9781439806180
  • Εκδότης: CRC PRESS
  • Σελίδες: 608
  • Έτος Έκδοσης: 2011
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Drug delivery technologies represent a vast and vital area of research and development in pharmaceutics. The demand for innovative drug delivery systems continues to grow, and this growth drives a variety of new developments. Building on the foundation provided by the second edition, Drug Delivery Systems, Third Edition covers the latest in research, development, and regulations in industry and academia.

The third edition of this popular book provides a comprehensive review of the latest research and development on drug delivery systems (including liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery); it also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. These topics are spread into five sections:

     

  • Site-specific drug delivery
  • Polymers and implantable drug delivery systems
  • Oral drug delivery
  • Transdermal, transmucosal, ocular, and miscellaneous drug delivery systems
  • Regulatory considerations and global outlook

Written in a straightforward, clear, and concise manner, the authors provide a global perspective on current and future advances and market opportunities. The book answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development and who desires an overview of the field, with extensive guidance on where to gain more information. Each chapter provides a table of marketed and investigational products, with numerous practical examples; the book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives.

Site-Specific Drug Delivery Using Liposomes and Emulsions as CarriersIntroduction

 

Liposomes in Drug Delivery

The Liposome-Drug Concept

Liposomes as Carriers of Therapeutic Agents

Parenteral Emulsions

Recent Advances and Future Prospects

Concluding Remarks

References

Site-Specific Drug Delivery Utilizing Monoclonal AntibodiesIntroduction

 

Production of Monoclonal Antibodies

Drug–Monoclonal Antibody Conjugates for Drug Targeting

Recent Studies with Monoclonal Antibodies

Conclusion and Basis for Future Trends

References

Role of Polymers in Drug DeliveryIntroduction

 

Currently Available Polymers

Soluble Polymers as Drug Carriers

Biodegradable or Bioerodible Polymers

Mucoadhesive Polymers

Polymers Containing Pendant Bioactive Substituents

Matrix Systems

Heparin-Releasing Polymers

Ionic Polymers

Oligomers

Miscellaneous

Recent Advances

Conclusion

References

Implants in Drug DeliveryIntroduction

 

Insulin Delivery as a Model Implant Pump System

Implants for Contraception

Delivery of Chemotherapeutic Agents Using Implants

Recent Advances in Implants and Related Devices (Excluding Inserts)

Future Prospects

References

Oral Drug DeliveryControlled-Release Formulations

 

Introduction

Features of the GI Tract

Targeting of Drugs in the GI Tract

Mathematical Models for Controlled-Release Kinetics

Design and Fabrication of Oral Delivery Systems

Survey of Oral Controlled-Release Products

Recent Advances

Current Development of Oral Drug Delivery Systems

Conclusion

References

Enhancing Oral BioavailabilityIntroduction

 

Increasing Bioavailability of Water-Insoluble Drugs

Increasing Bioavailability of Proteins, Peptides, and Other Drugs with Absorption Problems

Recent Advances and Future Prospects

References

Transdermal Drug DeliveryIntroduction

 

Theoretical Aspects of Transdermal Drug Delivery

Development of the Transdermal Therapeutic System

Examples of Transdermal Applications

Recent Advances and Future Prospects

Conclusion

References

Transmucosal and Ocular Drug DeliveryIntroduction: Transmucosal and Ocular Drug Delivery

 

Pulmonary Drug Delivery

Intranasal Drug Delivery

Buccal and Sublingual Drug Delivery

Rectal, Vaginal, and Other Forms of Transmucosal Drug Delivery

Ocular Drug Delivery

Conclusions and Future Outlook for Transmucosal

and Ocular Drug Delivery

References

Miscellaneous Forms of Drug DeliveryIntroduction

 

Pro-Drugs

Infusion Devices

Insulin Delivery

Recent Advances

Summary

References

Nanoscience and Nanotechnology for Drug DeliveryIntroduction

 

Nanotechnologies

Miscellaneous Applications of Nanomaterials

Nanoparticles and Nanostructures

Nanomedicine and Nanopharmaceuticals

References

Regulatory Considerations for Drug Delivery SystemsIntroduction

 

Current Status of Drug Delivery Technology

Submission of Documents for Manufacture and Quality

References

Drug Delivery Industry and the Global OutlookBasis for the Recent Trend

 

References

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