Epigenetics and Reproductive Health, Volume 21 1E

Συγγραφείς: Nafisa Balasinor , Priyanka Parte , Dipty Singh
ISBN: 9780128197530
Εκδότης: Elsevier
Σελίδες: 444
Έτος Έκδοσης: 2020

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Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.

Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.

Key Features

Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations
Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers
Features chapter contributions from international researchers in the field

SECTION I Spermatogenesis, oogenesis and fertility
CHAPTER 1 Epigenome reprogramming in the male and female germ line
CHAPTER 2 Genomic imprinting
CHAPTER 3 Chromatin remodeling of the male genome during spermiogenesis and embryo development
CHAPTER 4 Epigenetic regulation in stem cells
CHAPTER 5 Aberrant epigenetics and reproductive disorders

SECTION II Pregnancy/developmental/placental epigenetics
CHAPTER 6 Epigenetic reprogramming in the embryo
CHAPTER 7 Epigenetic regulation during placentation
CHAPTER 8 Epigenetic modulation during pregnancy and pregnancy related disorders
CHAPTER 9 Epigenetic involvement in fetal and neonatal origins of late-onset disease

SECTION III Epigenetic – lifestyle, aging and environmental influence
CHAPTER 10 Impact of environmental chemicals and endocrine disruptors on mammalian germ cell epigenome
CHAPTER 11 Influence of nutrition on reproductive health through epigenetic mechanisms
CHAPTER 12 Influence of stress and lifestyle on epigenetic modifications
CHAPTER 13 Aging of male and female gametes

SECTION IV Reproductive cancer and epigenetics
CHAPTER 14 Testicular and prostate cancers
CHAPTER 15 Emerging patterns and implications of breast cancer epigenetics: an update of the current knowledge
CHAPTER 16 Ovarian & endometrial cancers
CHAPTER 17 Epigenetic aberrations in cervical cancer

SECTION V Epigenetics in diagnosis, prognosis and therapy
CHAPTER 18 Natural molecules as epigenetic modifiers in reproduction