Essentials of Lung Transplantation

Lung transplantation (LTx) is a life-saving treatment for people with very severe end-stage lung diseases. This concise, well-illustrated practical handbook provides a comprehensive overview of pre-, peri- and post-transplant care addressing the complexity of lung transplantation, general follow-up, and common post-transplant complications through simple, to-the-point, short topics that answer questions that trainees, fellows and consultants working in LTx departments have. It educates healthcare professionals involved in the care of LTx patients by explaining the general post-transplant journey, addressing typical post-transplant complications, and providing examples of real-life cases.

Key Features:

1. Provides answers to common clinical questions during the post-transplant journey of a lung transplant recipient.

2. Shares practical/pragmatic approach to diagnostic and management issues seen in the lung transplant population for clinicians from both within and external to transplant centres internationally, to gain practical experience.

3. Summarises the clinical aspects of LTx, with easy to navigate short text blocks, bullet points and illustrations.

CONTENTS

1. Lung transplantation. 1.1 Lung transplantation: where are we today? 1.2 Ethical considerations regarding lung transplantation.1.3Clinical case: early post-operative evolution.

2. Pre-transplant. 2.1 Indications for lung transplantation. 2.2 How to select a good recipient? 2.3 A patient on the waiting list: how to manage and when to transplant. 2.4 How are organs allocated? 2.5 How to select a good donor?

3. Peri-transplant. 3.1 Type of lung transplantation. 3.2 Type of procedure. 3.3 ECMO, cardiopulmonary bypass and off-pump. 3.4 What is ischaemia time? 3.5 Should we use ex vivo lung perfusion? 3.6 To induce or not?

4. Post-transplant medication and follow-up. 4.1 Maintenance immunosuppression. 4.2 Prophylaxis. 4.3 What to expect after lung transplantation?. 4.4 General follow-up post-transplant. 4.5 Surgery in lung transplant patients. 4.6 Pregnancy and lung transplantation. 4.7 Medication interactions.

5. General post-operative complications and primary graft dysfunction . 5.1Pleural complications. 5.2 Ischaemic airway complications and fistulas. 5.3 Other post-operative complications. 5.4 Primary graft dysfunction (PGD).

6. Post-transplant complications: rejection. 6.1 Introduction acute and chronic rejection. 6.2 Hyperacute rejection: does it still exist?.6.3 Acute cellular rejection (ACR). 6.4 Donor specific antibodies (DSA): what and how to interpret?6.5 Antibody-mediated rejection (AMR). 6.6 Chronic rejection: chronic lung allograft dysfunction (CLAD). 6.7 Bronchiolitis obliterans syndrome (BOS). 6.8 Restrictive allograft syndrome (RAS). 6.9 Biomarkers and future therapies.

7. Other common post-transplant complications. 7.1 Infections. 7.2 Malignancies. 7.3 Kidney dysfunction. 7.4Metabolic complications and cardiovascular disease. 7.5 Reflux and other gastrointestinal issues: why it matters. 7.6 PRES: posterior reversible encephalopathy syndrome.

8. Clinical cases.