Handbook of Innovations in Central Nervous System Regenerative Medicine

• Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance
• Discusses the limitations of present therapies used in the clinics
• Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies
• Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Researchers, advanced graduate students, and neurologists

1. Insights on Nervous System Biology and Anatomy
   2. Introduction to Neurodegenerative Diseases
   3. Introduction to Trauma in CNS
   4. Impact of Neuro-inflammation in Injury and Disease in the CNS
   5. Current Clinical Approaches in Neurodegenerative Diseases
   6. Neuroprotection in the Injured Spinal Cord
   7. Immunomodelatory Approaches for Tackling Neuro-Inflammation
   8. Role of Fetal and Adult Tissues in CNS Regenerative Medicine
   9. Adult Stem Cells' Therapeutic Potential for Injured CNS
   10. iPSCs: An Essential Toolkit for Repair and Regeneration of the CNS?
   11. Biomaterial-Based Systems as Biomimetic Agents in the Repair of the CNS
   12. Tissue Engineering and Regenerative Medicine in CNS Repair
   13. New Trends in Drug Delivery in CNS Regeneration
   14. Gene Therapy Approaches in CNS Regenerative Medicine
   15. Gene Editing and CNS Regeneration
   16. Molecular Therapies in Neurodegeneration and Injury
   17. Deep Brain Stimulation and Parkinson's Disease
   18. Brain-Spinal Cord Interfaces
   19. Electroceuticals
   20. Secretome of Cells and Its Role in Neuroregeneration
   21. 3D Organoids and Bioreactors
   22. Microfluidics and Lab-on-a-Chip
   23. Translational Research: From Proof of Concept to Clinical Trials
   24. Advanced Therapies Medicinal Products
   25. Animal Models of CNS Disorders
   26. Bioethics in Translation Research and Clinical Trials