Hepatic Fibrosis: Mechanisms and Targets

• Presents progression from inflammation to fibrosis, with a special focus on the molecular mechanisms involved
• Didactically explains the participation of cells, cytokines and factors in profibrogenic pathways
• Illuminates the causative participation of free radicals in liver fibrogenesis
• Explains the role of gut dysbiosis in chronic liver diseases leading to fibrosis
• Provides experimental models to study liver fibrosis and describes available, noninvasive monitoring methods

1. Healthy and diseased extracellular matrix of the liver
2. From inflammation to fibrosis
3. Cells, cytokines, and factors involved in profibrogenic pathways
4. Role of free radicals in hepatic fibrogenesis
5. Role of gut dysbiosis in chronic liver disease leading to fibrosis
6. Alcohol-induced fibrosis
7. From fatty liver to nonalcoholic steatohepatitis with fibrosis
8. Viral hepatitis-induced liver fibrosis
9. Biliary fibrosis
10. Experimental models of hepatic fibrosis
11. Monitoring hepatic fibrosis

By Pablo Muriel, Researcher and Professor, Cinvestav-IPN, Mexico City, Mexico