Human Microbiome Clinical Implications and Therapeutic Interventions

The human microbiome refers to the complete microorganisms inhabiting the human body sites including skin, ear, nose, oral cavity, the genital, gastrointestinal and respiratory tracts, and body fluids such as breast milk, saliva, and urine. It is a significant and essential organ recognized for the body and has an established involvement in the host wellbeing, in terms of nutritional requirements and immunomodulation. This book talks about how alteration and imbalance in the same can have clinical implications associated with a multitude of gastrointestinal, lifestyle-associated, and neurodegenerative disorders. How the proliferation of specific groups of bacteria and their metabolic activities, as a result of intestinal dysbiosis leads to the 'leaky gut' condition thereby influences brain activity via the bidirectional gut-brain axis. It also coves the importance of microbial seeding and how it can be influenced by the mode of delivery, nutrition, and medication. This book also provides various therapeutic interventions such as the establishment of stool banks and Faecal microbiota transplantation (FMT) that have recently proved promising in the treatment of ASD, Inflammatory Bowel Disease, and Ulcerative Colitis. This book provides a deeper understanding of the development of the human gut microbiome and the factors driving its dysbiosis. This book is a valuable read for health professionals, medical students, nutritionists, and scientific research communities who are eager to update themselves with recent trends in microbiome research. It will also aid gastroenterologists and nutritionists to make well-informed choices regarding therapeutic regimes.

Table of contents (11 chapters)

1. Front Matter

   Pages i-xiii

    

2. Human Microbiome: Implication of Age and External Factors

   • Hilal Bashir, Anchal Bawa, Rashmi Kumar

   Pages 1-26

3. Oral Microbiome: An Opening to Healthy Possibilities

   • Sahana Vasudevan, Prasanna Neelakantan, Adline Princy Solomon

   Pages 27-54

4. Emerging Role of Gut Microbiota in Functional Gastrointestinal Disorders

   • Philip Augustine, Uday Chand Ghoshal, Rizwan Ahamed Zulfikar, Cyriac Abby Philips

   Pages 55-71

5. The Human Gut Microbiota and Gastrointestinal Cancer: Current Status and Therapeutic Perspectives

   • Goutam Chowdhury, Dharanidharan Ramamurthy

   Pages 73-107

6. Genetic and Epigenetic Regulation by Gut Microbe-Modulated Metabolites in Chronic Metabolic Diseases

   • S. Sumi, Chandrasekharan C. Kartha

   Pages 109-127

7. Gut Microbiota-Related Clinical Events and Therapeutic Interventions in Alcohol-Associated Liver Disease

   • Cyriac Abby Philips, Juan Pablo Arab, Xingshun Qi, Norihiro Imai, Philip Augustine

   Pages 129-145

8. Microbiota-Gut-Brain Axis in Neurological Disorders

   • Soumya Sundaram, Dinoop Korol Ponnambath, Sruthi S. Nair

   Pages 147-167

9. Modern Perspectives in Controlling Human Diseases through Probiotic Intervention

   • J. Devika Das, V. S. Akhila, Merin Paul, Aparna Shankar, Iype Joseph, Sabu Thomas

   Pages 169-192

10. Microbiome Association of Polypharmacy in Geriatric Population

    • Gururaja Perumal Pazhani, Murugan Veerapandian, Rajkumar Malayandi, Thandavarayan Ramamurthy

    Pages 193-213

11. Virome: Sentinels or Marauders in the Microbiome

    • Joydeep Nag, Nisha Asok Kumar, Reshma Koolaparambil Mukesh, Umerali Kunnakkadan, John Bernet Johnson

    Pages 215-240

12. Unlocking the Mysteries of the Human Microbiome to Combat COVID-19

    • Pushpanathan Muthuirulan, Meenakshi Bandyopadhyay, Sireesha Mamillapalli, Pooja Sharma

    Pages 241-264

    
    

    About the editor

    Dr. Sabu Thomas M.Sc., Ph.D. is a senior faculty scientist heading the Cholera and Biofilm Research Group at Rajiv Gandhi Centre for Biotechnology (National Institute under the Department of Biotechnology, Govt. of India). Dr. Thomas has been working in the area of environmental and clinical pathogenic bacteria for more than two decades, with a special focus on gut and chronic wound infected pathogens, antimicrobial resistance (AMR) and alternative strategies to curb AMR. Dr. Thomas’s team has published 13 book chapters and more than 80 research articles in prestigious journals at the national and international level, and edited two books. He has received various honors, including membership in the World Health Organization’s Global Task Force on Cholera Control. Currently, he is a member of the State Working Committee on Antimicrobial Resistance, and research coordinator for AMR activities in Kerala. He was part of the Second Indian Arctic Scientific Expedition team, formed by the Govt. of India to assess the bioprospecting potential of psychrophilic bacteria in the Polar region. He is also affiliated with various reputed organizations around the globe, including the Global Foodborne Infections Network, CHOLDInet - Global Laboratory Network for Cholera and other Diarrhoeal Infections, International Society for Infectious Diseases, and Freshwater Action Network South Asia.