Polycystic Ovary Syndrome: Current and Emerging Concepts, 2nd Edition

Now in a completely newly revised and expanded second edition, this comprehensive text presents the current state of the art in our understanding and management of polycystic ovary syndrome (PCOS), the most common hormonal disorder of reproductive aged women.  The numerous bothersome symptoms of PCOS include menstrual irregularities, hirsutism, acne, scalp hair thinning, weigh excess and infertility; additionally, as they age, women with PCOS are at a higher risk for metabolic abnormalities such as diabetes and dyslipidemias, as well as for cardiovascular disease and even certain cancers. Despite improvements in our understanding of this condition, the exact cause/s of PCOS remain elusive; genetic, hormonal, metabolic and environmental underpinnings are all suggested as relevant. 

All chapters have been updated, with eight new chapters added across seven thematic sections. Part one discusses the epidemiology of PCOS in both adults and adolescents. Part two covers the pathophysiology of PCOS, including genetics, the hypothalamo-pituitary-ovarian and the hypothalamo-pituitary-adrenal axes, insulin resistance, inflammation, and obesity. The next three sections present the various management strategies, medical and surgical, for harnessing the symptomatology, including PCOS-related infertility; these chapters include added case material to provide real-world examples of the treatments in action and their efficacy. Part six covers the comorbidities that women with PCOS commonly encounter, such as issues of mental health, sleep disturbances, endometrial hyperplasia, and cancer, as well as examines the economic burden of PCOS. The final section discusses emerging concepts surrounding possible mechanisms and potential therapeutic approaches to PCOS, including angiogenic dysfunction, the role of vitamin D, future potential therapies to targeted AMH signaling. The closing chapter, by familiarizing the readers with the intergenerational implications of PCOS and by raising awareness of potential “ripple effects”, aims at alerting the community on a need for vigilance as regards the health of PCOS progeny. 

With contributions from leaders in the field, Polycystic Ovary Syndrome, Second Edition remains the gold-standard text on this common medical condition and a valuable resource for the wide range of healthcare professionals engaged in caring for the women with PCOS (including but not limited to reproductive endocrinologists, gynecologists, family physicians, dermatologists, mental health professionals), for the aspiring women's health providers of tomorrow, and for the researchers who are striving to unravel the mysteries of the complex entity that PCOS is.

Table of Contents

Front Matter
Pages i-xviii

Epidemiology of Polycystic Ovary Syndrome
Front Matter
Pages 1-1

Diagnostic Criteria and Epidemiology of PCOS
Alexandria M. Freeman, Heather R. Burks, Robert A. Wild
Pages 3-11

Prevalence, Presentation, and Diagnosis of PCOS in Adolescents
Tania S. Burgert, Emily Paprocki
Pages 13-26

Polycystic Ovarian Syndrome: A Diagnosis of Exclusion
Mira Aubuchon
Pages 27-55

Pathophysiology, Endocrine, and Metabolic Milieus of Polycystic Ovary Syndrome
Front Matter
Pages 57-57

Recent Advances in the Genetics of Polycystic Ovary Syndrome
Michelle R. Jones, Mark O. Goodarzi
Pages 59-71

The Hypothalamic-Pituitary Axis in PCOS
Chinelo C. Okigbo, Sabrina Gill, Janet E. Hall
Pages 73-93

Ovarian Dysfunction in Polycystic Ovary Syndrome (PCOS)
Helen D. Mason, Nafi Dilaver, Suman Rice
Pages 95-120

The Role of the Adrenal Glands in the Hyperandrogenism Associated with the Polycystic Ovarian Syndrome
Ruth G. Freeman
Pages 121-132

Insulin Resistance and Lipotoxicity in PCOS: Causes and Consequences
Anne-Marie Carreau, Marie-Claude Battista, Jean-Patrice Baillargeon
Pages 133-154

Obesity, Dysmetabolic and Proinflammatory Milieu of Polycystic Ovary Syndrome
James J. Morong, Frank González
Pages 155-190

Management of Polycystic Ovary Syndrome
Front Matter
Pages 191-191

Managing PCOS in the Adolescent
Tania S. Burgert, Emily Paprocki
Pages 193-204

Managing the PCOS-Related Symptoms of Hirsutism, Acne, and Female Pattern Hair Loss
Trisha Shah, Harry J. Lieman
Pages 205-231

Role of Insulin-Sensitizing Drugs in PCOS Management
Dalal Kojok, Ghina Ghazeeri, Johnny T. Awwad
Pages 233-253

Role of Statins and Resveratrol in PCOS Management
Anna Sokalska, Israel Ortega, Antoni J. Duleba
Pages 255-277

Role of Lifestyle, Diet, and Exercise in the Management of Polycystic Ovarian Syndrome
Amy Plano
Pages 279-302

Management of Polycystic Ovary Syndrome Related Infertility
Front Matter
Pages 303-303

Managing PCOS-Related Infertility: Ovulation Induction, In Vitro Fertilization, and In Vitro Maturation
Saioa Torrealday, Pasquale Patrizio
Pages 305-327