Textbook of Diabetes and Pregnancy, 3rd Edition

Babies of women with diabetes are nearly five times more likely to be stillborn and almost three times more likely to die in the first three months. The incidence of gestational diabetes mellitus in the U.S. is high—between 3 and 7 percent—and rising. The condition is often complicated by other risk factors such as obesity and heart disease.

The Textbook of Diabetes and Pregnancy presents a comprehensive review of the science, clinical management, and medical implications of gestational diabetes mellitus, a condition with serious consequences that is on the increase in all developed societies. This new edition supports the latest initiatives and strategies of the International Federation of Gynecology and Obstetrics (FIGO) and adds chapters on noncommunicable diseases, obesity, bariatric surgery, and epidemiology outside Western cultures.

Written by a cadre of experts, the book provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.

Table of Contents

Introduction: Merging the Legacies and Hypotheses: Maternal Medicine Meets Fetal Medicine
Moshe Hod, Kypros Nicolaides, Hamutal Meiri, and Nicky Lieberman

History of Diabetic Pregnancy
David R. Hadden

Metabolism in Normal Pregnancy
Emilio Herrera and Henar Ortega-Senovilla

Intermediary Metabolism in Pregnancies Complicated by Gestational Diabetes
Bartolomé Bonet, María Bonet-Alavés, and Isabel Sánchez-Vera

Nutrient Delivery and Metabolism in the Fetus
William W. Hay, Jr., Paul J. Rozance, Stephanie R. Wesolowski, and Laura D. Brown

Pathogenesis of Gestational Diabetes Mellitus
Yariv Yogev

Autoimmunity in Gestational Diabetes Mellitus
Alberto de Leiva, Dídac Mauricio, and Rosa Corcoy

Epidemiology of Gestational Diabetes Mellitus
Yariv Yogev, Avi Ben Haroush, Moshe Hod, and Jeremy Oats

Genetics of Diabetic Pregnancy
Komal Bajaj and Susan J. Gross

Animal Models in Diabetes and Pregnancy Research
Catherine Yzydorczyk, Delphine Mitanchez, and Umberto Simeoni

Pathologic Abnormalities of Placental Structure and Function in Diabetes
Rhonda Bentley-Lewis, Maria Rosaria Raspollini, and Drucilla Roberts

The Great Obstetric Syndromes: The Roots of Disease
Rinat Gabbay-Benziv and Ahmet A. Baschat

Placental Origins of Diabesity and the Origin of Preeclampsia
Gernot Desoye and Berthold Huppertz

Diagnosis of Gestational Diabetes Mellitus
Donald R. Coustan and Boyd E. Metzger

Cost-Effectiveness of Screening and Management Programs for Gestational Diabetes Mellitus
Louise K. Weile, James G. Kahn, Elliot Marseille, and Nicolai Lohse

Changing Health Policy: From Study to National Policy
Ofra Kalter-Leibovici, Nicky Lieberman, Ronni Gamzu, and Moshe Hod

Ideal Weight Gain in Diabetic Pregnancy
Gerard H.A. Visser and Harold W. de Valk

Medical Nutritional Therapy for Gestational Diabetes Mellitus
Lois Jovanovic

Pharmacologic Treatment of Gestational Diabetes Mellitus: When to Start and What Agent to Use
Celeste P. Durnwald and Mark B. Landon

Gestational Diabetes Mellitus: The Consequences of Not Treating
Oded Langer

Gestational Diabetes Mellitus in Multiple Pregnancies
Matteo Andrea Bonomo and Angela Napoli

Glycemic Goals in Diabetic Pregnancy and Defining a "Good Control": Maternal and Fetal Perspective
Liran Hiersch and Yariv Yogev

Insulin Therapy in Pregnancy
Lois Jovanovic and John L. Kitzmiller

Use of Oral Hypoglycemic Agents in Pregnancy
Oded Langer

The Drug Dilemma of Oral Antidiabetic Agents in Pregnancy: Metformin
Yoel Toledano, Moshe Zloczower, and Nicky Lieberman

Facing the Noncommunicable Diseases’ Global Epidemic: The Battle of Prevention Starts In Utero the FIGO Challenge
Luis Cabero and Sabaratnam Arulkumaran

Links between Maternal Health and Noncommunicable Diseases
Anil Kapur

Diabetic Pregnancy in the Developing World
Eran Hadar, Eran Ashwal, and Moshe Hod

Managing Diabetic Pregnancy in China
Huixia Yang, Weiwei Zhu, and Rina Su

Gestational Diabetes Mellitus, Obesity, and Pregnancy Outcomes
Harold David McIntyre, Marloes Dekker-Nitert, Helen Lorraine Graham Barrett, and Leonie Kaye Callaway

Obesity Versus Glycemic Control: Which Contributes More to Adverse Pregnancy Outcome?
Amir Aviram and Yariv Yogev

Pharmacological Treatment for the Obese Gestational Diabetes Mellitus Patient
Fiona C. Denison and Rebecca M. Reynolds

Role of Exercise in Reducing the Risks of Gestational Diabetes Mellitus in Obese Women
Raul Artal

Role of Bariatric Surgery in Obese Women Planning Pregnancy
Ron Charach and Eyal Sheiner

Fetal Lung Maturity
Gian Carlo Di Renzo, Giulia Babucci, and Graziano Clerici

Monitoring during the Later Stage of Pregnancy and during Labor: Glycemic Considerations
Harold W. de Valk and Gerard H.A. Visser

Timing and Mode of Delivery
Salvatore Alberico and Gianpaolo Maso

Management of the Macrosomic Fetus
Federico Mecacci, Marianna Pina Rambaldi, and Giorgio Mello

Congenital Malformations in Diabetic Pregnancy: Prevalence and Types
Paul Merlob

Diabetic Embryopathy in the Preimplantation Embryo
Asher Ornoy and Noa Bischitz

Postimplantation Diabetic Embryopathy
Ulf J. Eriksson and Parri Wentzel

Fetal Malformations Detected with Magnetic Resonance Imaging in the Diabetic Mother
Tuangsit Wataganara

Continuous Glucose Monitoring in Pregnancy
Marlon Pragnell and Aaron Kowalski

Insulin Infusion Pumps in Pregnancy
Ilana Jaye Halperin and Denice S. Feig

Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy
Zoe A. Stewart and Helen R. Murphy

Noninvasive Glucose Monitoring
Itai Ben-David and Pierre Singer

Reproduction and Its Impact on Health and Disease
Sara Ornaghi and Michael J. Paidas

Diabetes, Pregnancy, and the Developmental Origins of Health and Disease
Gerard H.A. Visser and Mark A. Hanson

Interventions to Improve Pregnancy Outcome in Obese Pregnancy: Implications for Mother and Child
Rahat Maitland and Lucilla Poston

Lifestyle Interventions to Reduce Risk of Diabetes among High-Risk Pregnant and Postpartum Women
Lisa Chasan-Taber

Can Fetal Macrosomia Be Predicted and Prevented?
Maria Farren and Michael Turner

Hypoglycemia in Diabetic Pregnancy
Graziano Di Cianni, Cristina Lencioni, Emilia Lacaria, and Laura Russo

Hypertensive Disorders and Diabetic Pregnancy
Jacob Bar, Moshe Hod, and Michal Kovo

Diabetic Retinopathy
Nir Melamed and Moshe Hod

Diabetic Nephropathy
Elisabeth R. Mathiesen, Lene Ringholm, and Peter Damm

Diabetic Ketoacidosis
Annunziata Lapolla and Maria Grazia Dalfrà

Thyroid Disease in Pregnancy
Yoel Toledano and Gabriella Solomon

Quality of Care for the Woman with Diabetes at Pregnancy
Alberto de Leiva, Rosa Corcoy, Alejandra de Leiva-Pérez, and Eulàlia Brugués

Early Pregnancy Loss and Perinatal Mortality
Kinneret Tenenbaum-Gavish, Anat Shmuely, and Moshe Hod

Short-Term Implications of Gestational Diabetes Mellitus: The Neonate
Delphine Mitanchez, Catherine Yzydorczyk, and Umberto Simeoni

Long-Term Outcomes after Gestational Diabetes Mellitus Exposure in the Offspring
Delphine Mitanchez, Catherine Yzydorczyk, and Umberto Simeoni

Metabolomics and Diabetic Pregnancy
Angelica Dessì, Roberta Carboni, and Vassilios Fanos

Fetal Growth Restriction: Evidence-Based Clinical Management
Eduard Gratacós and Francesc Figueras