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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis
Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis
  • Συγγραφείς: Berencsi Gyorgy
  • ISBN: 9789400742154
  • Εκδότης: SPRINGER
  • Σελίδες: 472
  • Διαστάσεις: 155x235mm
  • Έτος Έκδοσης: 2012
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167,48€
Χωρίς ΦΠΑ: 158,00€
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Επιθυμητό Σύγκριση
  • Bidirectional maternal-fetal transport during pregnancy and long-term survival of cells
  • Fetal illnesses caused by receptor mediated maternal-fetal transport of autoimmune IgG
  • Receptor mediated transport of maternal anti-idiotypes may induce fetal TREG cells and fetal IgM
  • Biological therapy of malignancies of pregnants (monoclonal abs) may cause fetal impairment
  • Virus transport to the fetal body might result in later impairment of tumour defence mechanisms

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes.

The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy.

The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Table of contents 

Preface

  1. Barriers of the human organism and their Achilles’ heels; Berencsi, György III and Takács, Mária  
  2. Recent results on the development of fetal immune system: Self, epigenetic regulation, fetal immune responses; Ay, Eva, Buzas, Krisztina, Banati, Ferenc and Minarovits, Janos
  3. The role of endogenous retroviruses in the formation of syncytiotrophoblast and materno-fetal barrier; Ay, Eva, Banati, Ferenc, Turi-Balog, Katalin and Minarovits, Janos
  4. Maternal-fetal infections with human viruses; Berencsi, György III and Csire, Márta
  5. The mechanism and significance of integration and vertical transmission of human herpesvirus 6 genome; Arbuckle, Jesse H., Pantry, Shara and Medveczky, Peter G.
  6. Maternal-fetal transmission of HBV; Bhat, Purnima 
  7. Function of maternal idiotypic and anti-idiotypic antibodies as transgenerational messengers; Lemke, Hilmar, Tanasa, Radu I., Trad, Ahmad and Lange, Hans
  8. Polarised transfer of proteins through the syncytiotrophobalst and tissue culture cell lines; Berencsi György III and Ördög Katalin
  9. Fetal and neonatal illnesses caused or influenced by maternal transplacental IgG and/or therapeutic antibodies applied during pregnancy; Berencsi, György III and Szomor, Katalin
  10. Maternal-fetal microchimerism and fetal-juvenile malignancies; Berencsi, György III and Barcsay, Erzsebet
  11. Maternal tumours associated with and influenced by pregnancy; Berencsi, György III

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