Molecular Genetic Pathology, 2nd edition 2013

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.

Contents

Part I General Sections Section I: Basic Principles 1 Principles of Clinical Molecular Biology Shaobo Zhang, MD, Darrell D. Davidson, MD, PhD, and Liang Cheng, MD 2 Principles of Clinical Cytogenetics Stuart Schwartz, PhD, FACMG 3 Conceptual Evolution in Cancer Biology Shaobo Zhang, MD, Darrell D. Davidson, MD, PhD, Rodolfo Montironi, MD, Antonio Lopez-Beltran, MD, Gregory T. MacLennan, and Liang Cheng, MD 4 Genetic Inheritance and Population Genetics Tatiana Foroud, PhD, and Daniel L. Koller, PhD 5 Clonality Analysis and Tumor of Unknown Primary: Applications in Modern Oncology and Surgical Pathology Liang Cheng, MD, Shaobo Zhang, MD, Federico A. Monzon, MD, Timothy D. Jones, MD 6 Modern Immunohistochemistry in Targeted Therapy Allen M. Gown 7 Systems Pathology Jose Costa, MD and Michael Donovan, MD Section II: Methodology 8 Diagnostic Methodology and Technology Josephine Wu MD, Fei Ye MD, Miao Cui MD, Robert Shibata MD, Ruliang Xu MD, Liang Cheng MD, David Y. Zhang MD 9 Clinical Flow Cytometry Magdalena Czader, MD, PhD 10 Clinical Genomics in Oncology Hugo M. Horlings, MD, PhD Thalia Farazi, MD, PhD and Marc van de Vijver, MD, PhD 11 Clinical Proteomics David H. Geho, MD, PhD, Virginia Espina, MS, Lance A. Liotta, MD, PhD, Emanuel F. Petricoin, PhD, and Julia D. Wulfkuhle, PhD 12 Nanotechnology in Molecular Diagnostics Andrew N Young MD PhD and Brad A Kairdolf PhD 13 Gene Therapy: Vector Technology and Clinical Applications Sunyong Tang, PhD and Kenneth Cornetta, MD 14 Instrumentation for Molecular Testing Jordan Laser MD, Miao Cui MD, Bruce E. Petersen MD, Fei Ye MD, David Y. Zhang MD 15 Tissue Microarrays and Biomarker Validation Martina Storz, BS and Holger Moch, MD 16 Laser Capture Microdissection Liang Cheng MD, Shaobo Zhang MD, Darrell D. Davidson MD, Matthew Kuhar MD, Mingsheng Wang MD, David Y. Zhang MD, Gregory T. MacLennan MD 17 Human Tissue Biorepository William E. Grizzle, Katherine C. Sexton, Walter C. Bell 18 Pathology Informatics Roy E Lee MD, Long P Le MD PhD, John R Gilbertson MD Part II. Clinical Application and Disease-Based Sections Section III: Genetic Disorders 19 Prenatal Cytogenetic and Cytogenomic Diagnosis Ninette Cohen, PhD and Lisa Edelmann, PhD 20 Molecular Medical Genetics Lisa Edelmann, PhD, Stuart A. Scott, PhD, Liu Liu, PhD, Ruth Kornreich, PhD 21 Biochemical Genetics and Inborn Errors of Metabolism Chunli Yu, MD, Melissa Wasserstein, MD, George Diaz, MD, PhD 22 Molecular Genetics of Congenital Heart Disease Abigail E Southard, BA and Bruce D Gelb, MD 23 Familial Cancer Syndromes Beth Harrison, MD, Rodolfo Montironi, MD, Antonio Lopez-Beltran, MD, Michelle P. Elieff, MD, Liang Cheng, MD 24 Genetic Counseling Kimberly A Quaid, PhD and Lisa J Cushman, PhD Section IV: Molecular Microbiology 25 Molecular Virology Fei Ye MD, Miao Cui MD, Rame Khasawneh MD, Robert Shibata MD, Josephine Wu MD, Mona Sharaan MD, David Y. Zhang MD 26 Molecular Bacteriology and Mycobacteriology Jeong Hwan Shin, MD, PhD, Mona Sharaan, MD, Josephine Wu, DDS, CLSP(MB), CLDIR, Miao Cui, MD, David Y. Zhang, MD, PhD, MPH, Yi-Wei Tang, MD, PhD 27 Molecular Parasitology and Mycology Vincent J LaBombardi, PhD, Wei Wang, PhD 28 Molecular Microbiology in Transplantation Adnan A Alatoom, MD and Robin Patel, MD 29 Molecular Microbiology Epidemiology Miao Cui MD, Fei Ye MD, David Y. Zhang MD Section V: Hematologic Malignancies 30 Principle of Immunoglobulin and T Cell Receptor Gene Rearrangement Jeffrey E. Miller, PhD 31 Molecular Diagnostics of Lymphoblastic Leukemia and Lymphoma Zeqiu J Han, MD and Dan Jones, MD, PhD 32 Molecular Diagnostics of Myeloid Neoplasms C Cameron Yin, MD, PhD and Dan Jones, MD, PhD 33 Molecular Diagnostics of Lymphoid Malignancies Vasiliki Leventaki, MD and Francisco Vega, MD, PhD 34 Molecular Diagnostics of Myeloproliferative Neoplasms and Myelodysplastic Syndromes Gerlinde Wernig, MD, and Daniel A. Arber, MD 35 Molecular Diagnostics of Lymphoproliferative Disorders Timothy C. Greiner, MD Section VI: Hematological Disorders and Specialized Applications 36 Molecular Testing for Coagulation Abnormalities Veshana Ramiah, MD and Thomas L. Ortel, MD, PhD 37 Molecular Hemoglobinopathies Tina Y. Fodrie, BS, MT, MP (ASCP), Shaobo Zhang, MD, Minaxiben Patel, MT, MP (ASCP), Jodi A. Parks, MD, and Liang Cheng, MD 38 The HLA System and Transfusion Medicine: Molecular Approach S Yoon Choo, MD 39 Clinical Pharmacogenomics Catalina Lopez-Correa, MD, PhD and Lawrence M. Gelbert, PhD 40 Molecular Forensic Pathology Stephen R. Dlouhy, PhD and P. Michael Conneally, PhD 41 Specimen Identification and Bone Marrow Engraftment Analysis Loren J Joseph, MD 42 Circulating Tumor Cells: The Liquid Biopsy for Molecular Pathology Jeffrey S. Ross, MD Section VII: Laboratory Management 43 Ethical and Legal Issues in Molecular Testing Kimberly A. Quaid, PhD 44 Regulatory Issues in Molecular Testing Frank S. Ong MD, Wayne W. Grody MD PhD, Kingshuk Das, MD 45 Molecular Pathology Reporting Stacey S. O'Neill MD PhD and Margaret L. Gulley MD 46 Quality Assurance and Laboratory Inspection Kristin M. Post, MT(ASCP) and Liang Cheng, MD