Nanoparticles in Cancer Therapy. Innovations and Clinical Applications

This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance. Additionally, it explores nanotechnology in radiation therapy, phototherapy modalities and bioengineered virus-like nanoparticles for diagnostics and therapeutics. The last section reviews the clinical applications and prospects, examining theranostic nanoparticles, the clinical translation of nanomedicine and the current limitations of cancer nanotherapy. It also addresses future directions in nanoparticle application, and examines the genotoxicity, immunotoxicity, cytotoxicity assessments, safety profiles, targeted drug delivery, and their role in viral oncogenesis. This book is a useful resource for researchers, clinicians and students in the fields of oncology and nanotechnology.

CONTENTS

Chapter 1. Introduction to Cancer Biology. Chapter 2. Nanoparticles used in cancer therapy. Part II: Nanoparticles in Cancer Vaccines and Gene Therapy. Chapter 3. Polymeric nanoparticles as nanovaccine carriers for eliciting anticancer immunity. Chapter 4. Membrane-Based Nano-Vaccines for Immunotherapy. Chapter 5. Gene Therapy Utilizing Nanoparticles. Part III: Advanced Nanomedicine Approaches. Chapter 6. From Diagnosis to Treatment: The Role of Chemodynamic Nanoparticles in Cancer Theranostics. Chapter 7. Low-Dimensional Nanomaterials as an Emerging Platform for Cancer Diagnosis and Therapy. Chapter 8. Emerging Nano-based Strategies for Managing Drug Resistance in Cancer. Chapter 9. Nanotechnology-based Radiation Therapy to Cure Cancer. Chapter 10. Phototherapy Modalities Empowered by Nanotechnology. Chapter 11. Bioengineered Virus-Like Nanoparticles for Cancer Diagnostics and Therapeutics. Part IV: Clinical Applications and Future Prospects. Chapter 12. Theranostic Nanoparticles: Revolutionizing Cancer Diagnosis and Treatment. Chapter 13. Anti-Cancer Nanotherapeutics in Clinical Trials: The Work Behind Clinical Translation of Nanomedicine. Chapter 14. Limitations of Cancer Nanotherapy: Present Status and Future Prospects. Chapter 15. Current Challenges and Future Prospects in Nanoparticle Application. Chapter 16. Assessment of Genotoxicity and Immunotoxicity Nanoparticles: Overview and testing methods. Chapter 17. Assessment of Nanoparticles Induced Cytotoxicity and Safety Profiles. Chapter 18. Nanotechnology in Cancer Therapy: Targeted Drug Delivery and the Role in Viral Oncogenesis