Neurodegenerative Diseases. Translational Model, Mechanism and Therapeutics

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, 3D organoids in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modelling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.

Key Features:

         Provides comprehensive overview of neurodegenerative diseases and their models.

         Examines the limitations associated with modelling neurodegenerative diseases.

         Presents novel treatment strategies for Alzheimer’s disease using cellular models.

         Reviews importance of 3D organoid models for therapeutic approaches in Parkinson’s disease.

         Covers modeling techniques in understanding prion diseases.

         Explores the role of genetic models in understanding Huntington’s disease.

CONTENTS

1: General Introduction to Different Neurodegenerative Diseases.

2: Chemical-Induced Parkinson’s disease model and associated therapeutic strategies.

3: Recent advancement in the treatment of Parkinson’s disease cellular models.

4: Relevance of genetic model and linked therapeutics in Parkinson’s disease.

5: Importance of Newer 3D Organoids model based therapeutic approach in Parkinson’s disease.

6: Chemical Induced Alzheimer’s disease model and their therapeutic significance along with limitations.

7: Advancement in the Genetic Model of Alzheimer’s disease.

8: Organoids and Alzheimer’s disease.

9: Importance of Genetic Model in Huntington’s disease.

10: Natural source of drugs for neurodegenerative diseases.

11: Limitations of modelling in different neurodegenerative diseases.

12: Significance of 3D Organoid Model in Neurodegenerative Diseases.

13: Recent advancement in therapeutics of rare neurological disorders.

14: Bio-informatics based modeling in different neurodegenerative diseases and associated therapeutic strategies.

15: Holistic Management of Diverse Neurodegenerative Diseases in Different Translational Models.

16: Gene Therapy, OMICS Approaches, and Translational Neurodegenerative Models: Recent Advancements and Future Perspectives.

17: Implication and importance of Stem cell therapy in a translational model of neurodegenerative diseases.