Insular Epilepsies

The role of the insular cortex in epilepsy has been largely neglected until very recently. With growing interest in insular epilepsies, this book provides unique, in-depth coverage of the condition from childhood to adulthood. Detailed description of the anatomy, vascularization, connectivity, and functions of the insula along with complete description of the semiology, neurophysiology, and neuroimaging of insular epilepsy helps clinicians better recognize the condition. Up-to-date treatment avenues are explored, guiding the management of patients, including drug-resistant cases suitable for neurosurgery. Authors come from a range of backgrounds, providing a multidisciplinary perspective essential to all health professionals involved in epilepsy diagnosis and treatment. A scratch-off code in the inside cover allow users access to an online equivalent of the book, featuring videos illustrating the semiology of the various forms of insular seizures. This authoritative overview provides clinicians with the necessary information to treat this under-recognized condition.

•  Entirely devoted to insular cortex epilepsy, this book provides unique, in-depth coverage of the condition lacking in many major epilepsy textbooks, raising awareness of this long-neglected type of epilepsy.
• Contains detailed descriptions of insular epilepsy semiology, neurophysiology and neuroimaging, allowing readers to better recognize the condition and how best to investigate it.
• Describes a range of treatment avenues, ensuring readers are aware of the best treatment options available and can tailor them to each patient.
• Multidisciplinary in nature, a range of health professionals provide key insights into both diagnosis and treatment, as well as explaining the role and functions of the insula from a neuroscience perspective.
• Gain full HTML access of the whole book, with supplementary videos to illustrate the semiology of the various forms of insular seizures, via a scratch-off code inside the cover.

Contents
List of Contributors vii
Foreword by François Mauguière xi
1 A Brief History of Insular Cortex
Epilepsy 1
François Dubeau
Section 1 The Human Insula from an
Epileptological Standpoint
2 Anatomy of the Insula 11
Alexander Hammers
3 Vascularization of the Insula: Key Points for
Safe Epilepsy Surgery 26
Naoki Ikegaya and Masaki Iwasaki
4 Structural Connectivity of the
Insula 31
Jimmy Ghaziri, Phillip Fei, Laurent
Petit, and Dang Khoa Nguyen
5 Functional Connectivity of the
Insula 40
Leila Ayoubian, Jean-Didier
Lemaréchal, and Olivier David
6 Interoceptive Integration in the Primate
Insular Cortex 52
Henry C. Evrard
Section 2 The Spectrum of Epilepsies
Involving the Insula
7 Clinical Presentation of Insulo-Opercular
Epilepsy in Adults 67
Laurence Martineau, Dang Khoa
Nguyen, and Jean Isnard
8 Clinical Presentation of Insulo-Opercular
Epilepsy in Children 82
Michael S. Duchowny, Delphine
Taussig, and Petia S. Dimova

9 Are Painful Seizures Specific to Insular
Epilepsy? 98
Alexandra Montavont, Laure
Mazzola, Genevieve Demarquay, and
Jean Isnard
10 The Role of the Insula in Temporal Lobe
Epilepsy and Temporal Lobe “Plus”
Epilepsies 110
Carmen Barba and Philippe Kahane
11 Insular-Origin Seizures with
a Hypermotor Presentation 118
Koichi Hagiwara, Steve A. Gibbs,
Sylvain Rheims, and Lino Nobili
12 The Role of the Insula in Sudden
Unexpected Death in Epilepsy
(SUDEP) 134
Nuria Lacuey and Samden Lhatoo
Section 3 Noninvasive Investigation
of Insular Epilepsy
13 Noninvasive Electrophysiological
Investigations in Insular Epilepsy 141
Raluca Pana, Laurence Martineau,
Ismail Mohamed, Tao Yu, and Dang
Khoa Nguyen
14 Structural Imaging of Insular
Epilepsy 163
Andreas V. Alexopoulos
15 PET and SPECT in Insular
Epilepsy 179
Francine Chassoux and Jean-Paul Soucy
16 Neuropsychology of Insular Epilepsy 194
Olivier Boucher, Sallie Baxendale, Alain
Bouthillier, and Dang Khoa Nguyen

Section 4 Invasive Investigation
of Insular Epilepsy
17 Invasive Investigation of Insular
Epilepsy: Indications and
Preplanning 203
Philippe Ryvlin and Fabienne Picard
18 Invasive Investigation of Insular
Epilepsy: Surgical
Techniques 211
Alexander G. Weil and Francesco
Cardinale
19 Qualitative Interpretation of
Intracranial EEG in Insular
Epilepsy 227
Lorella Minotti, Rinki Singh,
Guillaume Martin, Dominique
Hoffmann, Laurence Martineau, and
Philippe Kahane
20 Quantitative Intracranial EEG
Signal Analysis in Insular
Epilepsy 238
Fabrice Bartolomei, Nicolas Roehri,
Rinki Singh, and Francesca Pizzo
21 Electrical Stimulation of the Human
Insular Cortex 246
Laure Mazzola, Jean Isnard, and
François Mauguière

Section 5 Surgical Management
of Insular Epilepsy
22 Insular Epilepsy Surgery: Surgical
Techniques and Experience of Various
Centers 257
Alain Bouthillier, Stephan Chabardes,
Massimo Cossu, and Jorge Gonzalez-
Martinez
23 Stereoelectroencephalography (SEEG)–
Guided Radiofrequency
Thermocoagulation (RFTC) of Insular
Epileptic Foci 266
Alice Rucar, Jean Isnard, and Marc
Guénot
24 Neurostimulation for the Treatment
of Insular Epilepsy 278
Patricia C. Dugan and Barbara
C. Jobst
25 Laser Interstitial Thermal Therapy (LITT)
for Insular Epilepsy 287
Azeem A. Rehman, Mark R. Lee, and
Dave F. Clarke
Epilogue 299
Index 300