Pediatric Liver Transplantation: A Clinical Guide

• The first book completely dedicated to the practice of pediatric liver transplantation
• Brief chapters organized by topic will include: definition of the topic, pathophysiology, conventional management, controversies, and a bulleted summary
• Edited by leaders in the field with worldwide contributors representing different specialties associated with pediatric liver transplantation

1. Evolution of transplantation medicine

BRIEF HISTORY OF PLT

HEALTH SYSTEM BACKGROUND REQUIREMENTS FOR PLT

2. Before transplantation

Brain death criteria

Non-heart beating donors

Donor procurement

Managing a scarce resource: Differences in donor allocation across the world

INDICATIONS AND CONTRAINDICATIONS (and their evolution) - General aspects

(List of diagnoses)

PREPARATION FOR PLT

Medical (immunisations/cardiac/renal/neurological aspects)

Surgical and Radiological aspects

Psychological/Social aspects

3. Paediatric liver transplantation

ANAESTHETIC ASPECTS (Risk assessment)

SURGICAL ASPECTS (Choice of donor for PLT, Prevention of thrombosis/anticoagulation)

SURGICAL TECHNIQUES

Split graft

Living-related

Auxiliary

Domino

Techniques and present role of hepatocyte transplantation

STRATEGIES IN IMMUNE SUPPRESSION (Immune ablation, renal-sparing, steroid-sparing)

4. Management after Transplantation

INTENSIVE CARE ASPECTS

ANTI-INFECTION STRATEGIES

Viral

Bacterial

Fungal

EARLY COMPLICATIONS

SURGICAL (biliary, vascular, etc.)

MEDICAL

ROLE OF HISTOLOGY AFTER PLT

ROLE OF RADIOLOGY AND INTERVENTIONAL RADIOLOGY AFTER PLT

LATE COMPLICATIONS

SURGICAL (graft re-modelling, secondary portal hypertension/shunts)

MEDICAL (recurrent disease post-PLT, de novo AIH, post-transplant lymphoproliferative disease, nephrotoxicity)

PSYCHOSOCIAL ASPECTS AFTER PLT

(social reintegration, medication adherence, family planning, education)

PROSPECTS FOR IMMUNE TOLERANCE (possibilities for safe withdrawal of immunosuppression)

TRANSITION TO ADULT SERVICES (smooth handover of care to a different system)

FUTURE REQUIREMENTS