New Technologies and Perinatal Medicine Prediction and Prevention of Pregnancy Complications

Table of Contents

List of contributors

Preface

Introduction: Why do we need Omics and Systems Biology
Joe Leigh Simpson and Moshe Hod

1. The Mother: Adaptation to Pregnancy and normal metabolism

Irene Cetin, Francesca Parisi, Alice Zavatta, and Roberta Milazzo

2. Maternal and fetal normal and abnormal nutrition

Sarah Louise Killeen, Eilleen C O’Brien, and Fionnuala M McAuliffe

3. The Great Obstetrical Syndromes: It's all in the placenta
Martin Gauster and Gernot Desoye

4. Embryo-specific communication and interaction with the maternal environment: The role of PreImplantation Factor
Eytan R Barnea and Michael Stark

5. Normal and abnormal fetal growth

Javier Caradeux, Eduard Gratacos, and Francesc Figueras

6. Pre-term labor and birth

Vincenzo Berghella and Eduardo da Fonseca

7. Gestational Diabetes Mellitus
Silvia Vannuccini and Federico Mecacci

8. Pre-eclampsia

Jon Hyett and Liona Poon

9. Maternal obesity

Tahir A. Mahmood and Rohan Chodankar

10. Maternal health: Immediate, short-, and long-term complications following pregnancy

Gil Gutvirtz, Omri Zamstein, and Eyal Sheiner

11. The fetus and the neonate: Immediate, short, and long term impact
Umberto Simeoni and Elie Saliba

12. The cost of pregnancy complications related to non-communicable diseases and the cost effectiveness of interventions to address them

Anil Kapur, Jon Hyett, and H David McIntyre

13. Integrated System Biology approaches to Fetal Medicine problems

Jezid Miranda, Fátima Crispi, and Eduard Gratacós

14. Omics and female reproduction

Galia Oron

15. The maternal genome and pregnancy outcomes
Nagendra K. Monangi, Ge Zhang, Mikko Hallman, Kari Teramo, Bo Jacobsson, and Louis J Muglia

16. Placental development and Omics

Sylvie Hauguel-de Mouzon, Gernot Desoye, and Silvija Cvitic

17. Placental metabolomics in obese pregnancies
Irene Cetin, Chiara Novielli, and Chiara Mandò

18. The methylome and epigenetics markers

Skevi Kyriakou, Marios Ioannides, George Koumbaris, and Philippos Patsalis

19. The microbiome and pregnancy complications
Maria Carmen Collado and Omry Koren

20. Small non-coding RNAs as biomarkers for pregnancy complications
Liron Yoffe, Meitar Grad, Avital Polsky, Moshe Hod, and Noam Shomron

21. Urine metabolomics and proteomics in prenatal health

Daniela Duarte, Maria do Céu Almeida, Pedro Domingues, and Ana M. Gil

22. The metabolomics and perinatal complications

Flaminia Bardanzellu, Moshe Hod, and Vassilios Fanos

23. Metabolomics in normal and pathologic pregnancies

Antonio Ragusa, Alessandro Svelato, and Sara D’Avino

24. Metabolomics in amniotic fluid

Alexandra-Maria Michaelidou, Foteini Tsakoumaki, Maria Fotiou, Charikleia Kyrkou, and Apostolos P. Athanasiadis

25. Omics and coagulation disorders in pregnancy

Sara Ornaghi and Michael J Paidas

26. The omics and preeclampsia
Piya Chaemsaithong and Liona C. Poon

27. Single Nucleotide Polymorphisms and pregnancy complications

Federica Tarquini, Giuliana Coata, Elena Picchiassi, and GianCarlo Di Renzo
28. Metabolomics and perinatal cardiology

Roberta Pintus, Angelica Dessì, and Vassilios Fanos

29. Metabolomics and human breast milk: a unique and inimitable food for infants

Flamina Cesare Marincola, Sara Corbu, Roberta Pintus, Angelica Dessì, and Vassilios Fanos

30. Neurodevelopment and placental omics
Despina D. Briana and Ariadne Malamitsi-Puchner

31. Early life complications, placental genomics, and the risk for neurodevelopmental disorders in the offspring

Pasquale Di Carlo, Giovanna Punzi, and Gianluca Ursini

32. Metabolomics and perinatal asphyxia

Ernesto d’Aloja, Emanuela Locci, Antonio Noto, Matteo Nioi, Giovanni Bazzano, and Vassilios Fanos

33. Environment, pregnancy complications, and omics

Chen Ben David and Ido Solt

34. Sleep and pregnancy complications

Orna Sever and Riva Tauman

35. Maternal plasma cell-free DNA screening: I. Basic science and applications
Peter Benn and Howard Cuckle

36. Maternal plasma cell-free DNA screening: II. Integration into clinical practice

Howard Cuckle and Peter Benn

37. Microarrays

Melissa Stosic, Jessica L. Giordano, Brynn Levy, and Ronald Wapner

38. Whole exome and whole genome sequencing
Mary E. Norton

Index

Editor(s)

Biography

Prof. Moshe Hod is Director of the Mor Comprehensive Women's Health Care Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel, President of the European Association of Perinatal Medicine, and Chairman of the FIGO  Hyperglycemia in Pregnancy Working Group. Eduard Gratacos is Head and Professor of Maternal-Fetal Medicine at Hospitals Clínic de Barcelona & Sant Joan de Déu, Barcelona, Spain. Vincenzo Berghella is Professor and Director, Division of Maternal-Fetal Medicine at Thomas Jefferson University, Philadelphia, PA, USA, and President of the Society for Maternal-Fetal Medicine. Mary E D'Alton is Willard C. Rappleye Professor of Obstetrics & Gynecology and Director of Services, Sloane Hospital for Women, and Chair of the Department of Obstetrics & Gynecology, Maternal-Fetal Medicine, Columbia University Medical Center, New York, NY, USA, and is a past president of the Society for Maternal-Fetal Medicine. Prof. Gian Carlo Di Rezo is Director of Perinatal and Reproductive Medicine Center and Midwifery School, University Hospital Perugia, Italy and Director of Permanent International and European School of Perinatal and Reproductive Medicine, Florence, Italy. Prof. Vassilios Fanos is Professor of Pediatrics and Director of Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy.