Synaptic Plasticity in Neurodegenerative Disorders

This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson’s Disease, Alzheimer’s Disease, and Huntington’s Disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases. Towards the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.

CONTENTS

Chapter 1: General Introduction to Different Neurodegenerative Diseases

Prabhakar Singh, Saqib Hassan, Kunal Biswas, V Ramesh Kumar

Chapter 2: Chemical-Induced Parkinson’s Disease Model and Associated Therapeutic Strategies

Sandhya Yadav, Manish Kumar Tripathi

Chapter 3: Recent Advancement in the Treatment of Parkinson’s Disease Cellular Models

Mansi Gandhi, Devhuti Palan

Chapter 4: Relevance of Genetic Model and Linked Therapeutics in Parkinson’s Disease

Kakarla Ramakrishna, Samuel Junior Osei Asokwah, Grace Mwihaki Njuguna, Hayiru Mohammed, Naresh Dumala, Matte Kasi Viswanadh, Guntupalli Chakaravarthi, Buchi N Nalluri, Vinjavarapu Lakshmi Anusha

Chapter 5: Importance of Newer 3D Organoids Model Based Therapeutic Approach in Parkinson’s Disease

Kakarla Ramakrishna, Hayiru Mohammed, Grace Mwihaki Njuguna, Samuel Junior Osei Asokwah, Vineeta Singh, Naresh Dumala, Matte Kasi Viswanadh, Vinjavarapu Lakshmi Anusha, Guntupalli Chakaravarthi, Buchi N Nalluri

Chapter 6: Chemical Induced Alzheimer’s Disease Model and Their Therapeutic Significance Along with Limitations

Ashutosh Gupta, Aakansha Pathak, Neeraj Kumar

Chapter 7: Advancement in the Genetic Model of Alzheimer’s Disease

Priti Kanik, Rashi Kumar, Ritu Varshney

Chapter 8: Organoids and Alzheimer’s Disease

Payal Singh, Shashank Shekhar Mishra, Pradeep Kumar

Chapter 9: Importance of Genetic Model in Huntington’s Disease

Mehak Bajaj, Mansi Gandhi, Devhuti Palan

Chapter 10: Natural Source of Drugs for Neurodegenerative Diseases

Chandrabhan Prajapati, Sachchida Nand Rai, Pooja Chaurasia, Shashank Shekhar Mishra, Anurag Kumar Singh, Santosh Kumar Singh

Chapter 11: Limitations of Modelling in Different Neurodegenerative Diseases

Chandra Prakash, Shyam Sunder Rabidas, Deepak Sharma

Chapter 12: Significance of 3D Organoid Model in Neurodegenerative Diseases

Ishita Bhardwaj, Atifa Haseeb Ansari, Raghvendra Pratap, Sippy Singh, Durgesh Singh

Chapter 13: Recent Advancement in Therapeutics of Rare Neurological Disorders

Faiza Parvez, Atifa Haseeb Ansari, Durgesh Singh, Sippy Singh

Chapter 14: Bio-Informatics Based Modeling in Different Neurodegenerative Diseases and Associated Therapeutic Strategies

Atifa Haseeb Ansari, Swayam Prabha Rai, Shivani Pathak, Sippy Singh

Chapter 15: Holistic Management of Diverse Neurodegenerative Diseases in Different Translational Models

Prabhash Kumar Pandey, Ashutosh Shrivastava, Anshuman Srivastava, Mohit, Amita Jain, Vimala Venkatesh, Soni Tiwari, Shiva Shukla, Farrukh Jamal

Chapter 16: Gene Therapy, OMICS Approaches, and Translational Neurodegenerative Models: Recent Advancements and Future Perspectives

Aakriti Sharma, Shashank Shekhar Mishra, Sandeep Singh

Chapter 17: Implication and Importance of Stem Cell Therapy in a Translational Model of Neurodegenerative Diseases

Shashank Kumar Ojha