Thalassemia, An Issue of Hematology/Oncology Clinics of North America, Volume 32-2

Description This issue of Hematology/Oncology Clinics, edited by Dr. Ali Taher, focuses on Thalassemia. Topics include, but are not limited to, Molecular basis and genetic modifiers; Evolving spectrum of epidemiology; Clinical classification; Ineffective erythropoiesis, anemia and iron overload; Hypercoagulability and vascular disease; Clinical complications and their management; Transfusion and iron chelation therapy; Hematopoietic Stem Cell Transplantation in Thalassemia; Gene therapy and genome editing; Emerging therapies; Quality of life; Advances in understanding pathophysiology and treatment of fertility, pregnancy, and prenatal diagnosis in Thalassemia; and MRI for iron overload. Author Info By Ali Taher, MD, PhD, FRCP, Professor of Medicine, Hematology & Oncology Director - Fellowship and Residents Research Program, Faculty of Medicine Associate Chair - Research, Department of Internal Medicine Deputy Director - Naef K. Basile Cancer Institute American University of Beirut Medical Center Beirut - Lebanon Professor of Hematology & Medical Oncology (Adj.) Emory School of Medicine Atlanta - USA

Table of Contents:

Thalassemia - Table of Contents

Erratum

Preface: Thalassemia

The Evolving Spectrum of the Epidemiology of Thalassemia

Molecular Basis and Genetic Modifiers of Thalassemia

Clinical Classification, Screening, and Diagnosis for Thalassemia

Ineffective Erythropoiesis: Anemia and Iron Overload

Clinical Complications and Their Management

Hypercoagulability and Vascular Disease

Interaction of Transfusion and Iron Chelation in Thalassemias

Iron Chelation Therapy as a Modality of Management

MRI for Iron Overload in Thalassemia

Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia

Hematopoietic Stem Cell Transplantation in Thalassemia

Gene Therapy and Genome Editing

Emerging Therapies