The Clozapine Handbook: Stahl's Handbooks (Stahl's Essential Psychopharmacology Handbooks)

 

• The increased interest in promoting greater clozapine use internationally means this book fills a gap in the market for clinicians who seek evidence-based advice on best practices
• Use of clozapine has shown real world benefits such as a reduction in suicidality, psychiatric hospitalization and mortality rates; many clinicians are unfamiliar with recent improvements in the understanding of clozapine-related dosing and adverse effect management
• Provides a logical, evidence-based framework for important clinical issues, leading the clinician through the reasoning process for adverse effect management and other common clinical situations.

 

Table of Contents

Preface

1. Initiating Clozapine
2. Understanding hematologic monitoring and benign ethnic neutropenia
3. Binding profile, metabolism, kinetics, drug interactions and use of plasma levels
4. Managing constipation
5. Managing sialorrhea
6. Managing sedation, orthostasis and tachycardia
7. Managing metabolic adverse effects
8. Managing seizure risk and stuttering
9. Fever, myocarditis, interstitial nephritis, DRESS, serositis and cardiomyopathy
10. Eosinophilia, leukocytosis, thrombocytopenia, thrombocytosis, anemia, hepatic function abnormalities
11. Managing enuresis and incontinence, priapism, venous thromboembolism, neuroleptic malignant syndrome, tardive dyskinesia and obsessive compulsive disorder
12. The efficacy story: treatment resistant schizophrenia, psychogenic polydipsia, treatment intolerant schizophrenia, suicidality, violence, mania and Parkinson's disease psychosis
13. Addressing clozapine positive symptom nonresponse in schizophrenia spectrum patients
14. Discontinuing clozapine and management of cholinergic rebound
15. Special topics: child and adolescent patients, elderly patients, patients with intellectual disability, pregnancy and risk for major congenital malformation, lactation, overdose, postmortem redistribution

Index.