Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions.

• Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected
• Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters
• Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation