Trends in mRNA Vaccine Research

The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines
In ‘Trends in mRNA Vaccine Research’, a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines. They also explore the regulatory and manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, Plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines.
Volume highlights include:
– A historical overview of mRNA vaccine development
– Immune responses to mRNA vaccines and the choice between modified or unmodified mRNA vaccines
– The use of circular RNA therapeutics, self-replicating RNA viruses, and GMP and up-scaling of mRNA vaccine production
– Latest data on mRNA vaccines current in development for tick-borne diseases, malaria and other parasitic diseases, AIDS, and cancer
Perfect for medicinal chemists, immunologists, and epidemiologists, ‘Trends in mRNA Vaccine Research’ will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.

CONTENTS

PART I: HOW mRNA VACCINES WORK
Historical overview
Immune responses to mRNA vaccines
mRNA vaccine platforms
mRNA delivery and formulation

PART II: REGULATORY QUESTIONS AND CHALLENGES IN VACCINE PRODUCTION
Ethical and regulatory issues
GMP and upscaling of mRNA vaccine production

PART III: mRNA PROPHYLACTIC VACCINES FOR IMMUNITY AGAINST PATHOGENS
SARS-CoV-2
Influenza
CMV, EBV
Flaviviruses
HIV
Rabies
Malaria
Tuberculosis

PART IV: mRNA THERAPEUTIC CANCER VACCINES
Tumor associated antigens
Tumor specific antigens

PART V: mRNA VACCINES FOR TOLERANCE
Atherosclerosis
Multiple sclerosis