Vitamin D as Progesterone - Like Hormone: Novel Applications in Obstetrics and Gynecology

Συγγραφείς: Vittorio Unfer (editor)
ISBN: 9781536175165
Εκδότης: Nova Publishers
Σελίδες: 309
Έτος Έκδοσης: 2020

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This book addresses a very interesting topic and offers a novel insight of the well-known Vitamin D. In the past, this molecule has been wrongly considered from health professionals and researchers as a “Vitamin”. The scientific community has now extensively accepted that calcitriol, commonly called “Vitamin” D, is a steroid (more precisely, a secosteroid) hormone. In this book series, the third volume titled “Vitamin D as Progesterone-like Hormone – Novel Applications in Obstetrics and Gynecology”, offers an innovative overview of the critical role played by Vitamin D in the therapeutic approach to common obstetric and gynecological disorders. The nuclear receptors of steroid hormones have common structure/function domains called “nuclear receptors superfamily”. Progesterone and Vitamin D receptors belong to two different classes of this superfamily. Throughout each chapter, we need to keep in mind this relationship as the core of our book.

Vitamin D exerts various and distinct physiological activities during gestation along with progesterone; in some cases, it may act also as its substitute or they may strengthen reciprocally. Like progesterone, Vitamin D seems extremely functional during the luteal phase onwards. A lot of research needs to be done in order to further investigate this novel fascinating role of Vitamin D. We can see the multiple activities also in combination with other molecules, such as alpha-lipoic acid and magnesium for controlling the uterine contractile activity, inositol and melatonin to support the luteal phase or epigallocatechin gallate in the management of uterine myomas. All these attractive insights will be discussed in the present book, analyzing in depth each aspect of this powerful molecule, bringing the instructions from this guide to everyday practice.

Foreword

Preface

Acknowledgements

Chapter 1. Evolution and Physiological Role of “Vitamin” D; Hormonal Nature and Progesterone-Like Activity in Pregnancy: An Overview
(Vittorio Unfer, MD, and Giovanni Monastra, Department of Experimental Medicine, Sapienza University, Rome, Italy)

Chapter 2. Vitamin D and Progesterone: Critical Analysis of the Functional Overlap in Immune Regulation
(Julia Szekeres-Bartho, MD, PhD, Department of Medical Biology, Pecs University, Medical School, Pecs, Hungary)

Chapter 3. Possible Role of Vitamin D in Embryo Adhesion and Implantation
(Maria Salomé Bezerra Espinola, MD, and Cesare Aragona, MD, Systems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, Italy)

Chapter 4. Vitamin D for the Prevention of Miscarriage and Spontaneous Preterm Birth
(Daniela Menichini, MD, and Fabio Facchinetti, MD, Mother Infant Department, University of Modena and Reggio Emilia, Modena, Italy)

Chapter 5. Vitamin D with Alpha-Lipoic Acid and Magnesium for Controlling Uterine Contractile Activity
(Imelda Hernández Marín, MD, Liliana Velázquez, PhD, and Juan Rivero, Biología de la Reproducción Humana, Universidad Nacional Autónoma de México, Ciudad de México, México)

Chapter 6. Vitamin D in Assisted Reproductive Technology (ART): The Therapeutic Regimen
(Stamatios Petousis, MD, PhD, Konstantinos Ravanos, MD, Chrysoula Margioula-Siarkou, MD, PhD, George Mavromatidis, MD, PhD, Konstantinos Dinas, MD, PhD, Yannis Prapas, MD, PhD, and Nikolaos Prapas, MD, PhD, IAKENTRO, Infertility Treatment Center, Thessaloniki, Greece, and others)

Chapter 7. A Support for the Luteal Phase: Supplementation with Vitamin D, Inositol and Melatonin
(Lidia Di Cerbo, MD, Conisha Holloman, MD, and Monica Longo, MD, PhD, Mother Infant Department, University of Modena and Reggio Emilia, Modena, Italy, and others)

Chapter 8. The Role of Vitamin D in the Management of Uterine Fibroids: The Possible Synergy with Epigallocatechin Gallate
(Giusy Porcaro, MD, and Beatrice Orrù, PhD, Women’s Health Center, Azienda USL Umbria, Orvieto, Italy, and others)

Chapter 9. Vitamin D and Cancer
(Noemi Monti., Sara Proietti, PhD, Alessandra Cucina, PhD, and Mariano Bizzarri, MD, PhD, Department of Experimental Medicine, Sapienza University of Rome, Systems Biology Group Lab, Rome, Italy, and others)

Index