Molecular Epidemiology: Applications in Cancer and Other Human Diseases

This volume covers factors that may predict response to treatment, outcome, and survival in molecular epidemiology.

It explores:

• design considerations (case-only, family-based, approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics, and incorporation of biomarkers in clinical trials)
• measurement issues (DNA biosampling methods, principles for high-quality genotyping, haplotypes, biomarkers of exposure and effect, and exposure assessment)
• methods of statistical inference (gene-gene and gene-environment interaction analysis, novel high-dimensional analysis approaches, pathway-based analysis methods, haplotype methods, dealing with race and ethnicity, risk models, and a discussion of reporting and interpreting results)

It also covers design considerations and includes scientific tables, equations, and pictures that provide a solid foundation for conducting and interpreting molecular epidemiological studies.