Paediatric Haematology and Oncology , 2E

• Concise yet comprehensive overview of all aspects of diagnosis and care of the child with haematological disorders and cancer
• Features clinical pearls on what to do at every stage of supporting the child and their family
• Contains handy reference ranges and useful websites

New to this Edition:

• Brand new chapters on the biology of childhood leukaemia and central nervous system tumours
• Greater focus on the expanded research on childhood malignancy and targeted treatments
• New clinical images to aid diagnosis from CT scans and MRIs

Fully revised and updated for its second edition, Paediatric Haematology and Oncology provides an easily accessible source of information about all of the basic principles of childhood cancer and leukaemia, and detailed specialist knowledge on how to care for children with those conditions. Featuring new chapters on the biology of childhood leukaemia and central nervous system tumours, the book includes a greater focus on the rapidly expanding research in the biology and genetics of childhood malignancy, as well as new clinical treatments and more detail on various tumour types.

Logically split into 12 sections on different aspects of haematology and cancer to allow quick and easy reference, the book provides general principles of diagnosis and treatment, short- and long-term care, and oncological emergencies, before moving on to chapters on specific diseases. Normal values and useful websites are also included for reference.

Chapters have been expanded to feature more clinical images to aid in diagnosis and interpretation, making this second edition an invaluable companion for the trainee and consultant in paediatric haematology and oncology.

Table of Contents

1 Introduction to paediatric haematology and oncology
1:Epidemiology of childhood cancer, Professor Mark Pearce
2:Overview of biology and genetics of childhood cancer, Professor Deborah Tweddle
3:Paediatric oncology in the developing world, Professor Alan Davidson
2 General approaches to suspected cancer
4:Abdominal mass, Dr Fiona Herd
5:Initial diagnosis of brain tumours, Professor Simon Bailey
6:The bleeding or bruising child, Dr Geoff Shenton
7:Lymphadenopathy, Dr Sunita Dhir
8:Imaging of brain tumours, Dr Dipayan Mitra
9:Imaging of non-CNS tumours, Dr Claire Gowdy and Dr Leigh McDonald
3 Haematological and oncological emergencies
10:Haematological and oncological emergencies, Dr Simon Bomken, Dr Heather Lambert, Dr Anita Devlin, Dr Britta Vormoor, Dr Tina Biss, Professor Simon Bailey, and Professor Rod Skinner
4 General principles
11:Multimodality treatment, Professor Simon Bailey
12:Systemic anticancer drugs, Professor Rod Skinner and Ms Lynzie Middleton
13:Paediatric radiotherapy, Dr Joanne Lewis
14:Surgery, Dr Hany Gabra
15:Haemopoietic stem cell transplantation, Professor Rod Skinner and Dr Wing Roberts
16:Clinical trials, Sister Lisa Price
5 Supportive care
17:Infection, Professor Marieke Emonts, Dr Lucia Pareja-Cebrian, and Professor Rod Skinner
18:Blood transfusion, Dr Peter Carey
19:Pain, Sister Kelley Mellett and Amanda Gerrard
20:Other aspects of supportive care, Professor Simon Bailey, Professor Rod Skinner, Ms Fiona Court, Dr Heather Borrill, Mr Hany Gabra, Dr Peter Carey
6 Long term follow up
21:Long-term follow-up of childhood cancer survivors, Professor Rod Skinner
7 Benign haematological diseases
22:Haemoglobinopathies, Dr Peter Carey
23:Haemostasis and thrombosis, Dr Tina Biss
24:Bone marrow failure, Professor Rod Skinner
25:Other non-malignant causes of peripheral blood cytopenias, Dr Peter Carey
8 Malignant haematological diseases
26:Biology of childhood leukaemia, Dr Frederik Van Delft
27:Acute lymphoblastic leukaemia, Professor Josef Vormoor
28:Acute myeloid leukaemia, Dr Geoff Shenton, Dr Wing Roberts, and Professor Rod Skinner
29:Acute leukaemia of ambiguous lineage, Professor Rod Skinner
30:Myelodysplasia, Professor Rod Skinner
31:Chronic myeloid leukaemia and other chronic myeloproliferative neoplasms, Professor Rod Skinner
32:Lymphoma, Dr Simon Bomken
9 Solid tumours
33:Neuroblastoma, Professor Deborah Tweddle
34:Retinoblastoma, Dr Helen Jenkinson
35:Renal tumours, Dr Quentin Campbell-Hewson
36:Bone tumours, Dr Quentin Campbell-Hewson
37:Extracranial germ cell tumours, Dr Matthew Murray
38:Soft tissue sarcomas, Dr Gail Halliday
39:Liver tumours, Dr Gail Halliday
10 Central nervous system tumours
40:Biology of central nervous system tumours, Professor Steven Clifford
41:Central nervous system tumours, Professor Simon Bailey and Professor Jeannette Parkes
11 Other conditions
42:Histiocytosis, Dr Kevin Windebank
43:Rare tumours, Professor Bernadette Brennan
12 New treatment strategies
44:New treatment strategies, Professor Darren Hargrave

Author Information

Contributors:

Simon Bailey
Professor of Paediatric Neuro Oncology and Consultant Pediatric Oncologist, Department of Paediatric Oncology, Great North Childrens' Hospital and Newcastle University, Newcastle Upon Tyne, Rowlands Gill, UK

Tina Biss
Consultant Haematologist, Department of Haematology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK

Simon Bomken
Clinician Scientist & Honorary Consultant Paediatric Oncologist, Department of Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK

Heather Borrill
Consultant Clinical Psychologist, Department of Psychology in Healthcare, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK

Bernadette Brennan
MAHSC Honorary Clinical Chair in Paediatric Oncology, Consultant Paediatric Oncologist, and Clinical Director of Research Governance for Manchester University Foundation Trust, Department of Paediatric Oncology, Royal Manchester Children's Hospital, Manchester, UK

Quentin Campbell-Hewson
Consultant Paediatric Oncologist, Great North Children's Hospital, Newcastle Upon Tyne, UK

Peter Carey
Consultant Haematologist and Directorate of Haematology and Clinical Oncology, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle Upon Tyne, UK

Steven Clifford
Director, Newcastle University Centre for Cancer & Professor of Molecular Paediatric Oncology, Newcastle University, Newcastle, UK

Fiona Court
Lead Dietitian in Paediatric Oncology, Department of Newcastle Nutrition, Royal Victoria Infirmary, Newcastle Upon Tyne, UK

Alan Davidson
Professor and Head of Clinical Unit, Department of Paediatrics and Child Health, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa

Frederik Van Delft
Newcastle University Research Fellow & Honorary Consultant in Adolescent Oncology, Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, UK

Anita Devlin
Consultant Paediatric Neurologist and Associate Clinical Lecturer, Department of Paediatric Neurology, Great North Children's Hospital, and Newcastle University, Newcastle-Upon-Tyne, UK

Sunita Dhir
Consultant Paediatric Oncologist, Department of Paediatric Oncology, University Hospitals of Leicester, Leicester, UK

Marieke Emonts
Professor of Paediatric Infectious Diseases, Newcastle University, and Paediatrician at Great North Children's Hospital, and Deputy Clinical Director Great North Children's Hospital, Newcastle, UK

Hany Gabra
Consultant Paediatric Surgeon, Great North Children's Hospital, Newcastle, UK

Amanda Gerrard
Children and Young Person's Oncology Outreach Nurse Specialist, Department of Paediatric Oncology, The Great North Children's Hospital, Newcastle Upon Tyne, Morpeth, UK

Claire Gowdy
Consultant Paediatric Radiologist, , Royal Victoria Infirmary, Newcastle Upon Tyne, UK

Gail Halliday
Consultant Oncologist, Department of Paediatric Oncology, Great North Children's Hospital, Newcastle Upon Tyne, UK

Darren Hargrave
Professor of Paediatric Neuro-oncology, Department of Paediatric Oncology, University College London, Great Ormond Street Institute of Child Health, London, UK

Fiona Herd
Medical Doctor, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK

Rebecca Hill
Academic Clinical Lecturer, Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, UK

Helen Jenkinson
Consultant Paediatric Oncologist, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK

Heather Lambert
Consultant Paediatric Nephrologist, Department of Paediatric Nephrology, The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK

Joanne Lewis
Consultant Clinical Oncologist, the Freeman Hospital's Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK

Leigh McDonald
Consultant Paediatric Radiologist, Department of Children's X-ray Radiology, Great North Children's Hospital, Newcastle, UK

Kelley Mellett
Children and Young Person's Oncology Outreach Nurse Specialist, Department of Paediatric Oncology, Great North Children's Hospital, Newcastle Upon Tyne, UK

Lynzie Middleton
Advanced Clinical Pharmacist, Department of Paediatric Oncology, Great North Children's Hospital, Newcastle Upon Tyne, UK

Dipayan Mitra
Consultant Neuroradiologist and Hon. Senior Lecturer, Department of Neuroradiology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK

Matthew Murray
Professor, Department of Pathology, University of Cambridge, Cambridge, UK

Lucia Pareja-Cebrian
Consultant Microbiologist, Newcastle Laboratories, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK

Jeannette Parkes
Professor and Head of Division, Radiation Oncology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa

Mark Pearce
Professor of Applied Epidemiology, Health Protection Research Unit, Newcastle University, Newcastle, UK

Lisa Price
Senior Research Sister, Department of Paediatric Oncology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK

Wing Roberts
Consultant Paediatric Haematologist, Department of Paediatric Haematology and Oncology, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle Upon Tyne, Tyne and Wear, UK

Geoff Shenton
Paediatric Haematologist, Department of Paediatric Oncology, Great North Children's Hospital, Newcastle-upon-Tyne, UK

Rod Skinner
Consultant in Paediatric Oncology / Bone Marrow Transplantation and Honorary Professor of Childhood Cancer, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, and Newcastle University, Newcastle, UK

Deborah Tweddle
Professor of Paediatric Oncology and Honorary Consultant in Paediatric & Adolescent Oncology, Wolfson Childhood Cancer Research Centre, Translational & Clinical Research Institute, Newcastle Centre for Cancer, Newcastle University and Great, North Children's Hospital, Newcastle Upon Tyne, UK

Britta Vormoor
Dr. Med. Paediatric Oncologist, Hemato-Oncology, Prinses Maxima Center for, Paediatric Oncology, Utrecht, Netherlands

Josef Vormoor
Clinical Co-Investigator and Clinical Director of Haemato-oncology Heidenreich group, Prinses Maxima Center for, Paediatric Oncology, Utrecht, Netherlands