The Peripheral T-Cell Lymphomas

THE PERIPHERAL T-CELL LYMPHOMAS

Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments

Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat.

For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource:

Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

Table of contents

List of contributors to be generated by the copy editor
Part 1: Biological Basis of the Peripheral T-Cell Lymphomas
1 Fundamentals T-Cell Lymphocyte Biology
Claudio Tripodo, Stefano Pilleri
2 Mechanisms of T-cell Lymphomagenesis
François Lemonnier, Philippe Gaulard, Laurence de Leval
3 Epigenetics of T-cell Lymphoma
H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen O’Connor, Sean Harrop
4 Animal Models of T-cell Lymphoma
Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe, Mamiko Sakata-Yanagimoto
Part 2: Epidemiology and Classification of the PTCL
5 The Geographic Distribution of the PTCL: Global Epidemiology
Amulya Yellala, Avyakta Kallam, James Armitage
6 Classification of the Peripheral T-Cell Lymphomas
Neval Ozkaya, Elaine Jaffee
7 Molecular Classification of the PTCLs
Tyler A. Herek, Javed Iqbal
Part 3: Discrete Clinical Subtypes of PTCL (Unique Epidemiology, Therapy and Management)
8 Peripheral T-Cell Lymphoma – Not Otherwise Specified
Nora Bennani, Stephen Ansell
9 Angioimmunoblastic T-cell Lymphoma (AITL)

Jehan Dupuis, Franck Morschhauser

10 The Spectrum of Anaplastic Large Cell Lymphoma

Jianping Kong, Andrew Feldman

11 HTLV-1-Positive Adult T-Cell Leukemia-Lymphoma (ATL)
Wataru Munakata, Kensei Tobina

12 Natural Killer/T Cell Lymphomas
S.J. Kim, R. Suzuki, A. Jaccard, S.T. Lim, Won Seog Kim
13 T-Prolymphocytic Leukemia (T-PLL)
Dima El-Sharkawi, Claire Deardon
14 Large Granular Lymphocytes Leukemia (LGL)
Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith, Thomas P. Loughran, Jr.
15 Gamma Delta T-cell Lymphomas
Francine Foss, Aadil Ahmed, Mina Xu
16 Enteropathy Associated T-Cell Lymphoma and Monomorphic Epitheliotropic Intestinal T-cell lymphoma
Craig R. Soderquist, Jennifer Shingleton, Sandeep Dave, Govind Bhagat
17 Hepatosplenic T-Cell Lymphomas

Robert N. Stuver, Mwanasha Merrill, Salvia Jain
18 Cutaneous T-Cell Lymphoma
Alejandro Ariel Gru, Bethanie Rooke, Kevin Molloy, Julia Scarsbrick
19 Other Rare Subtypes of PTCL
Pier Paolo Picaluga
Part 4: Treatment of the PTCL
20 Standard Front-line Therapies
Raphael Koch, Lorenz Truemper
21 Approved Agents in the Relapsed or Refractory Setting, Excluding Brentuximab vedotin
Helen Ma, Owen A. O’Connor
22 The Role for Autologous Stem Cell Transplantation (ASCT) in Peripheral T Cell Lymphomas (PTCL)
Juan Alejandro Ospina, H. Martinez-Cordero, J. Enciso, H. Idrobo
23 Allogeneic Stem Cell Transplantion
Anna Dodero, Paolo Corradini
24 Emerging Immunotherapy Approaches in Peripheral T-Cell Lymphomas
Barbara Pro, Andrei Shustov
25 Emerging New Small Molecules in Peripheral T-Cell Lymphomas
Alessandro Broccoli, Pier Luigi Zinzani
Part 5: Future Directions
26 The Value and Relevance of T-cell Lymphoma Registries
Tetiana Skrypets, Martina Manni, Monica Civallero, Iryna Kriachok, Massimo Federico
27 Innovative Chemotherapy-Free Approaches for the Treatment of PTCL
Enrica Marchi, Ahmed Sawas, Helen Ma, Luigi Scotto, Francesca Montanari
28 Global Collaborations
Dejan Radjeski, Eliza Hawke, Owen A. O’Connor, Pier Luigi Zinzani, WonSeog Kim, Enrica Marchi