Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8E

Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION

1. Voltage-gated sodium channels and electrical excitability of the heart

2. Voltage-gated calcium

3. Voltage-gated potassium channels

4. Structural and molecular bases of cardiac inward rectifier potassium channel function

5. Mammalian calcium pumps in health and disease

6. Structural and molecular bases of sarcoplasmic reticulum ion channel function

7. Organellar ion channels and transporters

8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannels

Section 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION

9. Structure-function relations of heterotrimetric complexes of sodium channel a and ß subunits

10. Regulation of cardiac calcium channels

11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome

12. Structural determinants and biophysical properties of hERG1 channel gating

13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents

14. Cardiac stretch-activated channels and mechano-electric coupling

15. Biophysical properties of gap junctions

16. Excitation-contraction coupling

Section 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION

17. Ion channel trafficking in the heart

18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.5

19. Fibroblast growth factor homologous factors modulate cardiac calcium channels

20. Macromolecular complexes and cardiac potassium channels

21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias

22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion an

Edited by Jose Jalife, MD, PhD, Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. and William Gregory Stevenson, MD, Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women's Hospital; Professor of Medicine Harvard Medical School, Boston, MA